Pluripotency without Proliferation

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Pluripotency without Proliferation Xiaodong Shu, Duanqing Pei  Cell  Volume 164, Issue 4, Pages 595-597 (February 2016) DOI: 10.1016/j.cell.2016.01.050 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Myc Controls Dormancy in Embryonic Stem Cells and Embryos (A) Embryonic stem cells (ESCs) have rapid cell cycle with short G1 phase and can enter G0 arrest upon depletion of Myc activity. (B) Estrogen deprivation or Myc inhibition by a small molecule induces embryonic diapause equivalent to dormant ESCs. Similar dormant states may also exist in other stem cells such as HSCs and CSCs. Cell 2016 164, 595-597DOI: (10.1016/j.cell.2016.01.050) Copyright © 2016 Elsevier Inc. Terms and Conditions

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