Salvage Lung Resection for Non-small Cell Lung Cancer After Stereotactic Body Radiotherapy in Initially Operable Patients Fengshi Chen, MD, PhD, Yukinori.

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Salvage Lung Resection for Non-small Cell Lung Cancer After Stereotactic Body Radiotherapy in Initially Operable Patients Fengshi Chen, MD, PhD, Yukinori Matsuo, MD, PhD, Akihiko Yoshizawa, MD, PhD, Toshihiko Sato, MD, PhD, Hiroaki Sakai, MD, PhD, Toru Bando, MD, PhD, Kenichi Okubo, MD, PhD, Keiko Shibuya, MD, PhD, Hiroshi Date, MD, PhD Journal of Thoracic Oncology Volume 5, Issue 12, Pages 1999-2002 (December 2010) DOI: 10.1097/JTO.0b013e3181f260f9 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Clinical course of patient 1. A, Chest computed tomography (CT) at stereotactic body radiotherapy (SBRT) showed a mass with 36 mm in diameter in the left upper lobe. B, Chest CT 5 months after SBRT demonstrated remarkable tumor shrinkage. C, Chest CT 10 months after SBRT revealed an apparent tumor relapse. Journal of Thoracic Oncology 2010 5, 1999-2002DOI: (10.1097/JTO.0b013e3181f260f9) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Pathologic findings (patient 1). A, (i) Cut surface of the resected lung after formalin fixation and (ii) loupe view showing a well-demarcated yellow-white nodular mass (arrowhead) in the center of fibrotic tissue caused by stereotactic body radiotherapy (SBRT) (dashed-line area). B, Microscopic appearance in the boundary area between a viable tumor nest (right lower area) and surrounding fibrotic tissue (left upper area). The field corresponds to the square in (A). Journal of Thoracic Oncology 2010 5, 1999-2002DOI: (10.1097/JTO.0b013e3181f260f9) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions