Surgical Preparation Abolishes Endothelium-Derived Hyperpolarizing Factor-Mediated Hyperpolarization in the Human Saphenous Vein Jian-An Yang, MD, Guo-Wei.

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Surgical Preparation Abolishes Endothelium-Derived Hyperpolarizing Factor-Mediated Hyperpolarization in the Human Saphenous Vein Jian-An Yang, MD, Guo-Wei He, MD, PhD The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 429-433 (February 1997) DOI: 10.1016/S0003-4975(96)00900-9

Fig. 1 Diagram of measuring and recording set-up for membrane potential of human saphenous vein in the organ bath. The Annals of Thoracic Surgery 1997 63, 429-433DOI: (10.1016/S0003-4975(96)00900-9)

Fig. 2 An actual trace of the membrane potential measurement in a single smooth muscle cell of the human saphenous vein. Concentration–response (membrane potential) curves were established for acetylcholine (ACh) in the presence of indomethacin (7 μmol/L) and NG-nitro-l-arginine (300 μmol/L) in the endothelium-intact (a), endothelium-denuded (b), and surgically prepared (c) human saphenous vein. The numbers refer to −log M concentrations. The Annals of Thoracic Surgery 1997 63, 429-433DOI: (10.1016/S0003-4975(96)00900-9)

Fig. 3 Concentration-dependent curves of membrane potential by acetylcholine (−9 to −5 log M) in normal human saphenous vein (control group). Vertical bars are 1 standard error of the mean of the response at each concentration. (Solid circle = control; open circles = in the presence of NG-nitro-l-arginine [LNNA, 300 μmol/L] and indomethacin [INDO, 7 μmol/L]; triangles = endothelium-denuded preparation [E−].) The Annals of Thoracic Surgery 1997 63, 429-433DOI: (10.1016/S0003-4975(96)00900-9)

Fig. 4 Concentration-dependent curves of membrane potential by acetylcholine (−9 to −5 log M) in the human saphenous vein undergoing surgical preparation (surgical preparation group). Vertical barsare 1 standard error of the mean of the response at each concentration. (Closed circles = control; open circles = human saphenous vein undergoing surgical preparation; triangles = endothelium-denuded preparation [E−]; ∗p < 0.05 compared with the control.) The Annals of Thoracic Surgery 1997 63, 429-433DOI: (10.1016/S0003-4975(96)00900-9)