T.M MacLeod, G Williams, R Sanders, C.J Green

Slides:

Advertisements

Similar presentations

Extracellular Matrix Bioscaffolds for Orthopaedic Applications by Jolene E. Valentin, John S. Badylak, George P. McCabe, and Stephen F. Badylak J Bone.

Advertisements

Maximising the use of tissue expanded flaps

In vitro tissue engineering of a cardiac graft using a degradable scaffold with an extracellular matrix–like topography Osamu Ishii, MD, Michael Shin,

The use of pimonidazole to characterise hypoxia in the internal environment of an in vivo tissue engineering chamber S.O.P. Hofer, G.M. Mitchell, A.J.

Therapeutic angiogenesis: A comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin Todd K. Rosengart, MD, Kurt.

Manoeuvring a-head in plastic surgery

S. Ghali, N. Bowman, U. Khan British Journal of Plastic Surgery

Peter W. Henderson, MD, George K

Dipeptidyl peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff Akio Koyama, MD, Kimihiro.

Mark F. Fillinger, MD, Emanuel R. Reinitz, MD, Robert A

The pyramidalis muscle free flap

Paclitaxel coating on the terminal portion of hemodialysis grafts effectively suppresses neointimal hyperplasia in a porcine model Insu Baek, PhD, Jinsun.

Dose responsive suppression of myointimal hyperplasia by dexamethasone

Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging Takeshi Funaki, MD, Koji Iihara, MD, PhD, Susumu.

Development of a “leak-proof,” knitted Dacron vascular prosthesis

Dipeptidyl peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff Akio Koyama, MD, Kimihiro.

True extracranial carotid artery aneurysm in a child

Bioabsorbable Gelatin Sheets Latticed With Polyglycolic Acid Can Eliminate Pericardial Adhesion Ichiro Yoshioka, MD, Yoshikatsu Saiki, MD, Kei Sakuma,

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps Francesca Polito, PhD, Alessandra Bitto, MD, PhD, Mariarosaria.

Prevention of perioperative vascular prosthetic infection with a novel triple antimicrobial- bonded arterial graft Ibrahim Aboshady, MD, Issam Raad, MD,

Regulation of new blood vessel growth into ischemic skeletal muscle

Cartilage MRI T2∗ relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease C.-Y. Wang, Y.-J. Peng,

Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical.

Endometrial stromal sarcoma invading the abdominal aorta treated with aortic replacement Brandon C. Busuito, BS, Charles Adger West, MD, Nabila Rasool,

Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material Soichiro Enomoto, MD, PhD, Makoto Sumi, MD,

Bone marrow-impregnated collagen matrix for wound healing: experimental evaluation in a microcirculatory model of angiogenesis, and clinical experience

Utilization of shape memory in external vein-graft meshes allows extreme diameter constriction for suppressing intimal hyperplasia: A non-human primate.

Takashi Nakamura, MD, Kotaro Suemitsu, MD, Junichi Nakamura, MD

Histological evaluation of Permacol™ as a subcutaneous implant over a 20-week period in the rat model T.M. Macleod, G. Williams, R. Sanders, C.J. Green

Manoeuvring a-head in plastic surgery

An “off the shelf” vascular allograft supports angiogenic growth in three-dimensional tissue engineering Johann M. Zdolsek, MD, Wayne A. Morrison, MB.

Endovascular aneurysmal models at the external iliac artery of dogs

Recycling spare tissues: splitting a bipedicled TRAM flap for reconstruction of the contralateral breast M Rietjens, F De Lorenzi, P Veronesi, O Youssef,

Paclitaxel coating of the luminal surface of hemodialysis grafts with effective suppression of neointimal hyperplasia Insu Baek, MS, Cheng Zhe Bai, PhD,

Use of Integra to resurface a latissimus dorsi free flap

Conformational stress and anastomotic hyperplasia

Covering small defects on the weight bearing surfaces of the foot: the free temporal fasciocutaneous flap O. Heymans, N. Verhelle, T. Lahaye British.

Harry M. Salinas, MD, Saiqa I. Khan, MD, Michael C

Vein graft failure Journal of Vascular Surgery

Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models Alan B. Lumsden,

Split-thickness skin grafting the high-risk diabetic foot

Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy Steven G.

Therapeutic angiogenesis: A comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin Todd K. Rosengart, MD, Kurt.

Manuel Caceres, MD, Natalia O. Glebova, MD, PhD

Saphenous vein biopsy: A predictor of vein graft failure

Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis Masayuki Kubo, PhD, Tao-Sheng Li, MD, PhD, Takahiro.

Hyaluronic acid prevents peripheral nerve adhesion

C.M Reardon, S O'Ceallaigh, S.T O'Sullivan

Maximising the use of tissue expanded flaps

Construction of a bioengineered cardiac graft

Adipofascial anterolateral thigh free flap for tongue repair

Volume 69, Issue 12, Pages (June 2006)

Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model

S. Ghali, N. Bowman, U. Khan British Journal of Plastic Surgery

Mark K. Hirko, MD, Joseph R. McShannic, MD, Steven P

Rationale and practical techniques for mouse models of early vein graft adaptations Peng Yu, MD, Binh T. Nguyen, MD, Ming Tao, MD, Christina Campagna,

Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

Up-regulation of vascular endothelial growth factor mrna and angiogenesis after transmyocardial laser revascularization Keith A Horvath, MD, Elaine Chiu,

Tissue regeneration observed in a porous acellular bovine pericardium used to repair a myocardial defect in the right ventricle of a rat model Yen Chang,

The effect of carbon coating and porosity on early patency of expanded polytetrafluoroethylene grafts: An experimental study Donald L. Akers, MD, Yong.

Carotid intraplaque hemorrhage: The significance of neovascularity

Does the end-to-end venous anastomosis offer a functional advantage over the end-to- side venous anastomosis in high-output arteriovenous grafts? Mark.

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia Giuseppe R Nigri, MD, PhD, Sylvie.

Reviewer Acknowledgment

Angioscope-assisted occlusion of venous tributaries with prolamine in in situ femoropopliteal bypass: Preliminary results of canine experiments John.

Primary reconstruction of anterior neck burns with free flaps

Late salvage of a free TRAM flap

Effects of argon laser on vascular materials

Prevention of perioperative vascular prosthetic infection with a novel triple antimicrobial- bonded arterial graft Ibrahim Aboshady, MD, Issam Raad, MD,

Malignant fibrous histiocytoma of the aorta

Presentation transcript:

Prefabricated skin flaps in a rat model based on a dermal replacement matrix Permacol™ T.M MacLeod, G Williams, R Sanders, C.J Green British Journal of Plastic Surgery Volume 56, Issue 8, Pages 775-783 (December 2003) DOI: 10.1016/S0007-1226(03)00383-7

Fig. 1 Diagrammatic representation of the stages of prefabrication: (A) isolation of the superficial epigastric vessels; (B) placement of a polyethylene sheet together with a piece of Permacol™ behind the vessels; (C) placement of a second piece of Permacol™ in front of the vessels (sandwiching the superficial epigastric vessels between them); and (D) isolation of the Permacol™ construct from the surrounding tissues with a second piece of polyethylene sheet. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 2 Process of prefabrication continued: (A) opening of the polyethylene sheet at 2, 4, 6 or 8 weeks; (B) skin graft application to the upper surface of the construct and ligation of the distal part of the vascular pedicle; and (C) the pedicled prefabricated Permacol™ flap. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 3 Macroscopic appearance of fibrous tissue encapsulating the polyethylene enclosed constructs. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 4 Photomicrograph of epigastric artery and vein on the surface of Permacol™ as seen intraoperatively (A) and 2 weeks postoperatively (B). Significant vascular outgrowth is seen from the epigastric pedicle onto inner surface of Permacol™ construct. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 5 Photomicrographs showing the outer surface of a standard Permacol™ construct 4 weeks after implantation of the epigastric pedicle. Blood vessels are seen to pass both (A) around the periphery of the construct and (B) through hair follicle remnants present within the matrix. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 6 Photomicrographs showing the outer surface of a standard Permacol™ construct: (A) 6 weeks after implantation of the vascular pedicle and (B) 1 week after application of a split thickness skin graft to its outer surface. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 7 Chart showing the percentage vascularity of: Laser treated 0.4 mm thickness Permacol™; Laser treated 0.75 mm Permacol™; Standard 0.75 mm thickness Permacol™ constructs; and Standard 1.5 mm thickness Permacol™ constructs 2, 4, 6 and 8 weeks after implantation of the epigastric vascular pedicle within the construct. Results shown are means±standard error of the mean of n=4 constructs at each time point. Laser treated Permacol™ constructs have a significantly greater percentage vascularity vs. standard Permacol™ constructs at all time points studied ***P<0.001. British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)

Fig. 8 Photomicrographs of laser treated Permacol™ construct showing: (A) the macroscopic appearance and (B) the microscopic appearance of blood vessels within the laser pores of the matrix. Histological section stained with Masson's trichrome (original magnification ×20). British Journal of Plastic Surgery 2003 56, 775-783DOI: (10.1016/S0007-1226(03)00383-7)