What Is the Core Oscillator in the Speract-Activated Pathway of the Strongylocentrotus purpuratus Sperm Flagellum? Luis U. Aguilera, Blanca E. Galindo,

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What Is the Core Oscillator in the Speract-Activated Pathway of the Strongylocentrotus purpuratus Sperm Flagellum? Luis U. Aguilera, Blanca E. Galindo, Daniel Sánchez, Moisés Santillán Biophysical Journal Volume 102, Issue 11, Pages 2481-2488 (June 2012) DOI: 10.1016/j.bpj.2012.03.075 Copyright © 2012 Biophysical Society Terms and Conditions

Figure 1 Schematic representation of the proposed speract-activated signaling-pathway in the S. purpuratus sperm flagellum. (Large rectangles) Physiological variables. (Small round boxes) Ionic exchangers, ionic channels and enzymes participating in this pathway. For a complete description of the molecules involved, see the main text and Table S1 of the Supporting Material. (Lines ending in arrows) Positive interactions; (lines ending in hammerheads) negative interactions. Biophysical Journal 2012 102, 2481-2488DOI: (10.1016/j.bpj.2012.03.075) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 2 Results of a deterministic simulation corresponding to a speract-activated sperm. Each plot represents the dynamics of a model variable versus time (10 s). Biophysical Journal 2012 102, 2481-2488DOI: (10.1016/j.bpj.2012.03.075) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 3 Results of a deterministic simulation for a speract-activated sperm treated with niflumic acid. Each plot represents the dynamics of a model variable versus time (50 s). Biophysical Journal 2012 102, 2481-2488DOI: (10.1016/j.bpj.2012.03.075) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 4 Results of a stochastic simulation for a speract-activated sperm. Each plot represents the dynamics of a model variable versus time (10 s). Biophysical Journal 2012 102, 2481-2488DOI: (10.1016/j.bpj.2012.03.075) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 5 Architectures of the system interaction network. (A) Complete network. (B) Interaction network after elimination of the Ca node. (C) Interaction network after elimination of the K node. (D) Interaction network after elimination of the Na node. (E) Interaction network after elimination of the Cl node. The corresponding simulations are shown in Fig. S1, Fig. S2, Fig. S3, and Fig. S4 of the Supporting Material. Biophysical Journal 2012 102, 2481-2488DOI: (10.1016/j.bpj.2012.03.075) Copyright © 2012 Biophysical Society Terms and Conditions