Volume 8, Issue 3, Pages 175-182 (June 2002) Glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats and the response to hormones  Cristiane Vicentino, Jorgete Constantin, Luciano Aparecido Stecanella, Adelar Bracht, Nair S. Yamamoto  Pathophysiology  Volume 8, Issue 3, Pages 175-182 (June 2002) DOI: 10.1016/S0928-4680(02)00003-2

Fig. 1 Glucose catabolism in livers from normal (A) and tumor-bearing rats (B) and the influence of glucagon. Livers from fasted rats were perfused as described in Section 2. Glucose (20 mM) was infused at 10–60 min and glucagon (10 nM) was infused at 40–60 min of perfusion, as indicated by the horizontal bars. The effluent perfusate was sampled in 2-min intervals and analyzed for glucose, lactate and pyruvate. Oxygen consumption was followed polarographically. The results in each graph are the means of four perfusion experiments. Vertical bars represent standard errors of the means. Pathophysiology 2002 8, 175-182DOI: (10.1016/S0928-4680(02)00003-2)

Fig. 2 Time courses of the accumulated extra outflow of glucose due to glucagon or norepinephrine in livers from control and tumor-bearing rats. Livers of fed rats were perfused as described in Section 2. After a pre-perfusion period, glucagon (10 nM) or norepinephrine (1 μM) was infused. The accumulated extra glucose that was released under hormonal stimulus was calculated according to Eq. (2). Pathophysiology 2002 8, 175-182DOI: (10.1016/S0928-4680(02)00003-2)