What is an “eosinophilic phenotype” of asthma?

Slides:



Advertisements
Similar presentations
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Severe adult-onset asthma: A distinct phenotype
D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Clarification concerning amoxicillin skin testing
Fatty acids, inflammation, and asthma
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Atopic dermatitis: Age and race do matter!
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD 
David A. Khan, MD  Journal of Allergy and Clinical Immunology 
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Patient perspectives on the management of atopic dermatitis
Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents
Fatty acids, inflammation, and asthma
An Infant with Atopic Dermatitis and Itching After Ingestion of Milk
Rising prevalence of asthma is sex-specific in a US farming population
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
The National Biome Initiative: An allergy perspective
Nonadherence to Asthma Treatment: Getting Unstuck
Peter M. Wolfgram, MD, David B. Allen, MD 
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
Reply Journal of Allergy and Clinical Immunology
A survivor: The eosinophil as a regulator in asthma
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Early decreases in blood eosinophil levels with reslizumab
What are the best outcome measurements for atopic eczema
The Management of Eosinophilic Esophagitis
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A
News Beyond Our Pages Journal of Allergy and Clinical Immunology
A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity  Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Claus Bachert, MD, PhD, Cezmi A. Akdis, MD 
Effect of ingested H1 antihistamines on methacholine challenge
Cephalosporin Side Chain Cross-reactivity
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Personalized asthma therapy in blacks—the role of genetic ancestry
Autophagy: Nobel Prize 2016 and allergy and asthma research
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L
New pathways for itching in patients with atopic dermatitis?
News Beyond Our Pages Journal of Allergy and Clinical Immunology
One step forward, 2 steps back: The enigma of preschool wheeze
Risk of oral food challenges
Benjamin Chaigne, MD, Hervé Watier, MD, PhD 
Measles and immunomodulation
The Editors' Choice Journal of Allergy and Clinical Immunology
Consumer attitudes and risks associated with packaged foods having advisory labeling regarding the presence of peanuts  Susan L. Hefle, PhD, Terence J.
Macrolide antibiotics and asthma treatment
Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge  Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.
Asthma: The past, future, environment, and costs
Pedro Giavina-Bianchi, MD, PhD, Shih-Wen Huang, MD 
Environmental factors and eosinophilic esophagitis
Systemic responses after bronchial aspirin challenge in sensitive patients with asthma  Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,
Dietary therapy for eosinophilic esophagitis
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Advances in pediatric asthma in 2007
Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts  Helen Chapel, MA,
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Safety and efficacy of repeated monthly carboplatin desensitization
Natural history of cow’s milk allergy
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Primary prevention of asthma and allergy
Itching as a systemic disease
Presentation transcript:

What is an “eosinophilic phenotype” of asthma? Parameswaran Nair, MD, PhD, FRCP, FRCPC  Journal of Allergy and Clinical Immunology  Volume 132, Issue 1, Pages 81-83 (July 2013) DOI: 10.1016/j.jaci.2013.05.007 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Poor correlation between blood eosinophils (× 106/L) and sputum eosinophils (percentages; A) and between blood eosinophils (× 106/L) and sputum eosinophils (106/mL; B) at baseline in patients who entered a clinical trial of mepolizumab for severe eosinophilic asthma.11 Journal of Allergy and Clinical Immunology 2013 132, 81-83DOI: (10.1016/j.jaci.2013.05.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions