mTOR Regulation by JNK: Rescuing the Starving Intestinal Cancer Cell?

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Presentation transcript:

mTOR Regulation by JNK: Rescuing the Starving Intestinal Cancer Cell? H. Nikki March, Douglas J. Winton Gastroenterology Volume 140, Issue 5, Pages 1387-1391 (May 2011) DOI: 10.1053/j.gastro.2011.03.027 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Network interactions between Wnt, AKT/mTOR, and JNK pathways. (A) The activated mTOR complex promotes translation and ribosome biosynthesis, and lies downstream of Akt regulation of the TSC1/2 complex. There is substantial modulation of this pathway by components of the Wnt pathway, including GSK-3β and Dvl2. Note the positive feedback provided by the S6 Kinase (S6K) activated by mTOR. The newly recognized role for JNK in regulating the mTOR pathway is both direct (via Raptor) and indirect (via S6K). (B) As well as collaborating to regulate mTOR, the Wnt and JNK pathways operate synergistically to regulate common transcription targets. Gastroenterology 2011 140, 1387-1391DOI: (10.1053/j.gastro.2011.03.027) Copyright © 2011 AGA Institute Terms and Conditions