Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte.

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Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group Thomas Schroeder, Elena Rachlis, Gesine Bug, Matthias Stelljes, Stefan Klein, Nina Kristin Steckel, Dominik Wolf, Mark Ringhoffer, Akos Czibere, Kathrin Nachtkamp, Ariane Dienst, Mustafa Kondakci, Michael Stadler, Uwe Platzbecker, Lutz Uharek, Thomas Luft, Roland Fenk, Ulrich Germing, Martin Bornhäuser, Nicolaus Kröger, Dietrich W. Beelen, Rainer Haas, Guido Kobbe Biology of Blood and Marrow Transplantation Volume 21, Issue 4, Pages 653-660 (April 2015) DOI: 10.1016/j.bbmt.2014.12.016 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Overall survival (OS) after treatment with Aza and DLI in 154 patients. OS was 29% (±4%) at 2 years. Biology of Blood and Marrow Transplantation 2015 21, 653-660DOI: (10.1016/j.bbmt.2014.12.016) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Overall survival (OS) after treatment with Aza and DLI according to diagnosis and disease burden. Type of relapse (eg, molecular instead of hematological relapse), primary diagnosis of MDS, and a lower leukemic burden in BM at relapse were associated with a longer OS in multivariate analysis. (A) Patients with MDS (blue curve) and AML (green curve), log-rank: P = .001. (B) AML patients according to type of relapse and BM blast count: molecular relapse (blue curve, log-rank: P < .001), hematological relapse <13% blasts (green curve, log-rank: P = .0602), and hematological relapse >13% blasts (grey curve). Biology of Blood and Marrow Transplantation 2015 21, 653-660DOI: (10.1016/j.bbmt.2014.12.016) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions