Lois A. Salamonsen, Ph. D. , Tracey Edgell, Ph. D. , Luk J. F

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Presentation transcript:

Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery Lois A. Salamonsen, Ph.D., Tracey Edgell, Ph.D., Luk J.F. Rombauts, M.D., Ph.D., Andrew N. Stephens, Ph.D., David M. Robertson, Ph.D., Adam Rainczuk, Ph.D., Guiying Nie, Ph.D., Natalie J. Hannan, Ph.D. Fertility and Sterility Volume 99, Issue 4, Pages 1086-1092 (March 2013) DOI: 10.1016/j.fertnstert.2012.09.013 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The intrauterine environment for implantation. (A) In the uterine cavity, glandular secretions including nutrients, enzymes, cytokines, antiproteases, and transport proteins provide the milieu for final blastocyst development and attachment. (B) At the luminal epithelial surface, changes include those in the glycocalyx (e.g., mucins), along with adhesion molecules such as integrins. Within the luminal and glandular epithelial cells, changes occur in junctional complexes, Ca++ regulators, and secreted molecules as above. Fertility and Sterility 2013 99, 1086-1092DOI: (10.1016/j.fertnstert.2012.09.013) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Molecular changes in endometrial tissue between the proliferative and secretory phases. Differentially regulated proteins, initially identified by differential two-dimensional gel electrophoresis, were validated by immunohistochemistry. Upper panel: CLIC1 is detected in epithelium predominantly during the midsecretory phase. Lower panel: PGRMC1 is present in the stromal compartment maximally during the proliferative phase. Brown coloration represents positive staining. Fertility and Sterility 2013 99, 1086-1092DOI: (10.1016/j.fertnstert.2012.09.013) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions