Severe Hepatic Fibrosis in Schistosoma mansoni Infection Is Controlled by a Major Locus That Is Closely Linked to the Interferon-γ Receptor Gene Alain.

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Presentation transcript:

Severe Hepatic Fibrosis in Schistosoma mansoni Infection Is Controlled by a Major Locus That Is Closely Linked to the Interferon-γ Receptor Gene Alain J. Dessein, Dominique Hillaire, Nasr Eldin M.A. Elwali, Sandrine Marquet, Qurashi Mohamed-Ali, Adil Mirghani, Sandrine Henri, Ahmed A. Abdelhameed, Osman K. Saeed, Mubarak M.A. Magzoub, Laurent Abel The American Journal of Human Genetics Volume 65, Issue 3, Pages 709-721 (September 1999) DOI: 10.1086/302526 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Segregation of the six markers of the 6q22-q23 region in two families, indicating, for each subject, the phenotype, age, and the haplotype minimizing the number of recombinants for the six markers. Alleles inferred from other relatives are displayed in outline italic. The likely susceptibility haplotypes are boxed. Recombinations are indicated by arrowheads. The American Journal of Human Genetics 1999 65, 709-721DOI: (10.1086/302526) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Penetrance, according to exposure time, predicted by model IV of table 3, for AA subjects and Aa males. The American Journal of Human Genetics 1999 65, 709-721DOI: (10.1086/302526) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint analysis showing the location of SM2 in relation to the following four markers: D6S1009, FA1, D6S310, and D6S308. The horizontal axis represents the genetic distance (in cM), with the intragenic IFN-γR1 marker FA1 chosen as the origin. The American Journal of Human Genetics 1999 65, 709-721DOI: (10.1086/302526) Copyright © 1999 The American Society of Human Genetics Terms and Conditions