Absence of a vestibular phenotype in CIB2−/− mice

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Absence of a vestibular phenotype in CIB2−/− mice Absence of a vestibular phenotype in CIB2−/− mice A, BThe vestibular utricular hair cells (UHCs) of P7 CIB2−/− mice have normal MET responses. (A) The panels on the left show the mechanical stimulation protocol, with examples of MET currents in control (black) and CIB2−/− (dark‐light red traces) UHCs. (B) The MET current values and the mean amplitude‐displacement relationships (I(X), right panel) show near normal MET responses in CIB2−/− (n = 5) UHCs, as compared to age‐matched CIB2+/− mice (n = 5) (mean ± SD). (Welch's t‐test; “ns” indicates a statistically non‐significant difference, P = 0.39).CVestibular behavioural tests (platform, trunk–curl, contact–righting and swim tests). Unlike Ush1g−/− mice (green, month 3, n = 3), the CIB2−/− mice (red, month 3, n = 7, and month 7, n = 7) have no vestibular dysfunction, displaying similarly performances to age‐matched control CIB2+/− mice (black, month 3, n = 6 and month 7, n = 5) (mean ± SD). Being roughly similar, the values at months 3 and 7 were combined (Welch's t‐test; *P = 0.098 for platform test, ***P = 0.007 for contact righting, and trunk curl tests, and **P = 0.019 for swim test).DRepresentative open‐field exploratory behaviour (2 min) by a 3‐month‐old mouse is shown for each genotype. Quantification of the number of rotations in 120 seconds (mean ± SEM), showing that, unlike Ush1g−/− mice, which display the circling behaviour typical of USH1, CIB2−/− mice have no vestibular defects (Welch's t‐test; ***P = 0.009 for rotations count) (n = 5 for CIB2+/− and CIB2−/− mice; and n = 3 for Ush1g−/− mice).E, FTop views of UHCs from CIB2−/− P90 mice, showing preserved and normally shaped hair bundles (E), contrasting with the severe loss at this stage of the hair bundles in the cochlea (F). Scale bars: 2 μm. Vincent Michel et al. EMBO Mol Med. 2017;9:1711-1731 © as stated in the article, figure or figure legend