Clostridium difficile toxin testing by National Health Service (NHS) acute Trusts in England: 2008–2013 S.M. Gerver, A.P. Johnson, R.J. Hope Clinical.

Slides:

Advertisements

Similar presentations

O. Dauwalder, L. Landrieve, F. Laurent, M. de Montclos, F

Advertisements

Rectal bacteriotherapy for recurrent Clostridium difficile-associated diarrhoea: results from a case series of 55 patients in Denmark 2000–2012 M. Tvede,

Cryptococcosis—the impact of delay to diagnosis

J.-C. Lagier Clinical Microbiology and Infection

A comparison of two molecular methods for diagnosing leptospirosis from three different sample types in patients presenting with fever in Laos K. Woods,

Comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis A vaccine in healthy Chinese children aged 18 months to 16 years:

O.J. Dyar, G. Tebano, C. Pulcini Clinical Microbiology and Infection

D. Khalil, M. Hultin, M.U. Rashid, B. Lund

Impact of an intervention to control Clostridium difficile infection on hospital- and community-onset disease; an interrupted time series analysis J.

Thirty day all-cause mortality in patients with Escherichia coli bacteraemia in England J.K. Abernethy, A.P. Johnson, R. Guy, N. Hinton, E.A. Sheridan,

Association of vancomycin serum concentrations with efficacy in patients with MRSA infections: a systematic review and meta-analysis T. Steinmetz, N.

European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection.

Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications T.-L. Liao, Y.-M.

Migrant health—a cause for concern?

Host factors are more important in predicting recurrent Clostridium difficile infection than ribotype and use of antibiotics Y.H. van Beurden, S. Nezami,

Therapy of acute gastroenteritis: role of antibiotics

Screening of migrants for tuberculosis identifies patients with multidrug-resistant tuberculosis but is not sufficient P. Helbling Clinical Microbiology.

R. Cantón Clinical Microbiology and Infection

A. F. Simonetti, C. Garcia-Vidal, D. Viasus, D. García-Somoza, J

Comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis A vaccine in healthy Chinese children aged 18 months to 16 years:

Dermatitis by Dermatophilus congolensis

Is the prevalence of antibiotic-resistant organisms changing in Canadian hospitals? Comparison of point-prevalence survey results in 2010 and 2012 V.

Trends in length of stay, mortality and readmission among patients with community- acquired bacteraemia M. Søgaard, R.W. Thomsen, R.B. Bang, H.C. Schønheyder,

Clinical characteristics and outcome of patients with Clostridium difficile infection diagnosed by PCR versus a three-step algorithm C. Beaulieu, L.-L.

First isolation of Akkermansia muciniphila in a blood-culture sample

H. Adibhesami, M. Douraghi, M. Rahbar, A. Abdollahi

Hepatitis C: global epidemiology and strategies for control

Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficile infection Sarah M. Bartsch, Craig A. Umscheid,

Asymptomatic Clostridium difficile colonization in two Australian tertiary hospitals, 2012– 2014: prospective, repeated cross-sectional study L. Furuya-Kanamori,

Low sensitivity of fecal toxin A/B enzyme immunoassay for diagnosis of Clostridium difficile infection in immunocompromised patients S. Erb, R. Frei,

Enhanced surveillance of carbapenemase-producing Gram-negative bacteria to support national and international prevention and control efforts R. Freeman

Identification of patients at high risk for Clostridium difficile infection: development and validation of a risk prediction model in hospitalized patients.

B. Huttner, S. Harbarth, D. Nathwani

Epidemiology of opportunistic infections in AIDS patients

I. Al Shukri, F. Hamilton, M. Evans, S. Cooper, G. McKenzie, L

Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit E. Theocharidou, B. Agarwal, G. Jeffrey,

The role of tigecycline in the management of Clostridium difficile infection: a retrospective cohort study E. Manea, J. Sojo-Dorado, R.E. Jipa, S.N.

L. Fenner, A. F. Widmer, A. Stranden, M. Conzelmann, A. Goorhuis, C

Mathematical modeling of Clostridium difficile infection

Gender differences in treatment outcomes of tuberculosis patients in Taiwan: a prospective observational study J.-Y. Feng, S.-F. Huang, W.-Y. Ting, Y.-C.

An outbreak of Clostridium difficile infections due to new PCR ribotype 826: epidemiologic and microbiologic analyses M.J.T. Crobach, A.F. Voor in 't.

S. David, M. Mentasti, J. Parkhill, V.J. Chalker

Laboratory diagnosis of Clostridium difficile disease

European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection M.J.T.

Symposia and Oral Presentations

Impact of obesity on the risk of wound infection following surgery: results from a nationwide prospective multicentre cohort study in England S. Thelwall,

Systematic review of antibiotic consumption in acute care hospitals

Detection of nosocomial Clostridium difficile infections with toxigenic strains despite negative toxin A and B testing on stool samples J. Stahlmann,

N. Jazmati, M. Hellmich, B. Ličanin, G. Plum, A.J. Kaasch

Vaccinations against respiratory tract infections at Hajj

Predicting the risk of Clostridium difficile infection following an outpatient visit: development and external validation of a pragmatic, prognostic risk.

How well does physician selection of microbiologic tests identify Clostridium difficile and other pathogens in paediatric diarrhoea? Insights using multiplex.

Sequential time to positivity of blood cultures can be a predictor of prognosis of patients with persistent Staphylococcus aureus bacteraemia M.-S. Hsu,

S. M. Bartsch, J. A. McKinnell, L. E. Mueller, L. G. Miller, S. K

Increasing numbers of hospitalizations and deaths with mention of Clostridium difficile infection, north-eastern Italy, 2008–2013 U. Fedeli, E. Schievano,

Statin use and clinical outcomes among pneumonia patients

Microbiologic factors affecting Clostridium difficile recurrence

Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle A. Dalhoff,

C.P. Kelly Clinical Microbiology and Infection

O. Dauwalder, L. Landrieve, F. Laurent, M. de Montclos, F

Shorter duration of antibiotic treatment for acute bacteraemic cholangitis with successful biliary drainage: a retrospective cohort study A. Doi, T.

R. Khatib, G. Simeunovic, M. Sharma, M. G. Fakih, L. B. Johnson, L

First implementation of frozen, capsulized faecal microbiota transplantation for recurrent Clostridium difficile infection into clinical practice in Europe

Trends and changes in Clostridium difficile diagnostic policies and their impact on the proportion of positive samples: a national survey A. Adler, Y.

J.L. Balcázar Clinical Microbiology and Infection

Typing of Clostridium difficile

CMI editorial report, 2016 Clinical Microbiology and Infection

The burden of chikungunya in the Pacific

CMI readers' survey Clinical Microbiology and Infection

Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection A. Russo, M. Falcone, M. Fantoni, R. Murri,

Presentation transcript:

Clostridium difficile toxin testing by National Health Service (NHS) acute Trusts in England: 2008–2013 S.M. Gerver, A.P. Johnson, R.J. Hope Clinical Microbiology and Infection Volume 21, Issue 9, Pages 850.e1-850.e4 (September 2015) DOI: 10.1016/j.cmi.2015.04.013 Copyright © 2015 Terms and Conditions

Fig. 1 Rate of C. difficile toxin testing, stool examinations and C. difficile infections per year: 2008–2013. The Clostridium difficile infection rates are for all-reported cases of C. difficile and not those that are Trust-apportioned [11]. This is because the stool examinations and C. difficile toxin test data cannot be stratified to the same granularity achievable with patient-level C. difficile infection data, which includes knowing the individual date of specimen and date of admission to an acute Trust for each case. To be consistent when comparing rates of stool examinations, C. difficile toxin tests and C. difficile infections, occupied bed-days were used as the denominator for all rate calculations. Data are from the 143 acute Trusts with complete quarterly laboratory data only. Clinical Microbiology and Infection 2015 21, 850.e1-850.e4DOI: (10.1016/j.cmi.2015.04.013) Copyright © 2015 Terms and Conditions

Fig. 2 Comparison of expected and observed rates of C. difficile infections per year: 2008–2013. The expected rate of Clostridium difficile infections (CDI) per 100 000 bed-days was calculated using the ratio between C. difficile toxin tests and C. difficile infections as observed in 2008 (i.e. 16.9 C. difficile toxin tests for each C. difficile infection) remained the same for the following 5 years (2009–2013). This has been plotted against the observed rate of CDI. Clinical Microbiology and Infection 2015 21, 850.e1-850.e4DOI: (10.1016/j.cmi.2015.04.013) Copyright © 2015 Terms and Conditions