Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

Manuel J. Antunes, MD, PhD, DSc

Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting Rainald.

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.

Studies of hypoxemic/reoxygenation injury: With aortic clamping

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Ground glass opacity of the lung: The veil that needs lifting

Walter J. Scott, M.D., Bruce L. Gewertz, M.D.

The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: A simple finite element analysis Mark B. Ratcliffe,

Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor David A. Bull, MD, Rafe C. Connors,

Heart reduction surgery: An analysis of the impact on cardiac function

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Controlled reperfusion prevents pulmonary injury after 24 hours of lung preservation Ari O Halldorsson, MD, Michael Kronon, MD, Bradley S Allen, MD, Shaikh.

Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and NA+/K+/2CL- cotransport inhibition on extracellular potassium accumulation.

Improved myocardial protection in minimally invasive aortic valve surgery with the assistance of port-access technology Shubjeet Kaur, MDa, Jorge Balaguer,

Detrimental Effects of Cardiopulmonary Bypass in Cyanotic Infants: Preventing the Reoxygenation Injury Bradley S. Allen, MD, Shaikh Rahman, MS, Michel.

Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions Motohisa Tofukuji, MD, PhDa,

Harold L. Lazar, MD The Journal of Thoracic and Cardiovascular Surgery

Studies of hypoxemic/reoxygenation injury with aortic clamping

Gerald D. Buckberg, MD, Kai Ihnken, MD, Kiyozo Morita, MD

The lord of the rings Antonio Miceli, MD, PhD

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Normokalemic adenosine–lidocaine cardioplegia: Importance of maintaining a polarized myocardium for optimal arrest and reanimation Kathryn L. Sloots,

Editorial: The core of leadership

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Myocardial protection in normal and hypoxically stressed neonatal hearts: The superiority of hypocalcemic versus normocalcemic blood cardioplegia Kirk.

Support Your Specialty

A first start for lung transplantation?

Ventricular volume, chamber stiffness, and function after anteroapical aneurysm plication in the sheep Mark B. Ratcliffe, MDa, Arthur W. Wallace, MD,

Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy

Cardioplegia and vascular injury

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Management of vasodilatory shock after cardiac surgery: Identification of predisposing factors and use of a novel pressor agent Michael Argenziano, MD,

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Aging reduces postischemic recovery of coronary endothelial function

Reply Journal of Vascular Surgery

Leora B. Balsam, MD, Abe DeAnda, MD

Niv Ad, MD, Lawrence M. Wei, MD

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Reviewer Acknowledgment

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Sunil P Malhotra, MD, Stephan Thelitz, MD, R. Kirk Riemer, PhD, V

Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

Discussion The Journal of Thoracic and Cardiovascular Surgery

Tai Ji: The law of inflammatory response

Tissue valve, nitinol stent, or storage solution

The future of cardiac surgery training: A survival guide

The continuing challenge of congenital heart disease in China

Between a rock and a hard place

Michael T. Kronon, MD, Bradley S

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

Goya V. Raikar, MD, Kunikazu Hisamochi, MD, Bao-Lan N

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

George D. Lilly 1906–1988 Journal of Vascular Surgery

Minimally invasive direct coronary artery bypass, percutaneous transluminal coronary angioplasty, and stent placement for left main stenosis William.

Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution Jeffrey M. Pearl,

Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.

Did you like Terminator 3 better than Terminator 2

Masao Takahashi, MD, Shinichiro Yamamoto, MD, Shigeki Tabata, MD

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

Contribution of hyperoxia to lipid peroxidation in coronary artery operations: Should we keep a low oxygen tension? Leonidas Hadjinikolaou, MD, Andrew.

Presentation transcript:

The relationship between calcium and magnesium in pediatric myocardial protection Michael Kronon, MD*, Kirk S. Bolling, MD, Bradley S. Allen, MD, Shaikh Rahman, MS, Tingrong Wang, MD, Ari Halldorsson, MD, Harold Feinberg, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 114, Issue 6, Pages 1010-1019 (December 1997) DOI: 10.1016/S0022-5223(97)70015-1 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 LV systolic function as measured by the end-systolic elastance (EES) and expressed as a percentage of baseline values. Systolic function is completely preserved, independent of the presence of magnesium, in hearts protected with a hypocalcemic cardioplegic solution. Hearts protected with a normocalcemic cardioplegic solution alone exhibited marked loss of systolic function. In contrast, magnesium enrichment of the normocalcemic cardioplegic solution offset the detrimental effects of high levels of calcium, resulting in complete return of systolic function. *p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 1010-1019DOI: (10.1016/S0022-5223(97)70015-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 LV diastolic compliance as measured by the end-diastolic pressure volume relationship and expressed as percent increased stiffness compared with baseline values. Only a minimal increase in diastolic stiffness is observed in hearts protected with hypocalcemic cardioplegic solutions independent of the presence of magnesium. A marked increase in diastolic stiffness is observed in hearts protected with a normocalcemic solution without magnesium enrichment. Conversely, when magnesium is added to the normocalcemic cardioplegic solution, diastolic compliance is maintained. *p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 1010-1019DOI: (10.1016/S0022-5223(97)70015-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Overall LV myocardial function measured by PRSW and expressed as percent recovery compared with baseline values. Global myocardial function is completely preserved, independent of the presence of magnesium, in hearts protected with a hypocalcemic cardioplegic solution. In hearts protected with a normocalcemic cardioplegic solution, there is marked loss of global myocardial function in the absence of magnesium enrichment. Conversely, magnesium enrichment offsets the detrimental effects of high-calcium cardioplegic solution, preserving PRSW. *p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 1010-1019DOI: (10.1016/S0022-5223(97)70015-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 CVR measured during each cardioplegic infusion. There is no difference in CVR in hearts protected with a hypocalcemic solution or a normocalcemic solution enriched with magnesium. Conversely, there is a marked rise in CVR when a normocalcemic cardioplegic solution was infused in the absence of magnesium enrichment, indicating a coronary vascular injury. *p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 1010-1019DOI: (10.1016/S0022-5223(97)70015-1) Copyright © 1997 Mosby, Inc. Terms and Conditions