Prognostic value of bronchiolo-alveolar carcinoma component of small lung adenocarcinoma Masahiko Higashiyama, MD, Ken Kodama, MD, Hideoki Yokouchi,

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Prognostic value of bronchiolo-alveolar carcinoma component of small lung adenocarcinoma Masahiko Higashiyama, MD, Ken Kodama, MD, Hideoki Yokouchi, MD, Koji Takami, MD, Masayuki Mano, MD, Shoji Kido, MD, Keiko Kuriyama, MD The Annals of Thoracic Surgery Volume 68, Issue 6, Pages 2069-2073 (December 1999) DOI: 10.1016/S0003-4975(99)01064-4

Fig 1 Classification based on the extent of well differentiated bronchiolo-alveolar carcinoma (BAC) within the tumor tissue. (A) Type I, tumor has no BAC component (0%). (B) Type II, tumor less than 50% BAC. (C) Type III, more than 50% BAC. (D) Type IV 100% BAC. The right-upper corner shows a high-power magnification of each tumor tissue. The Annals of Thoracic Surgery 1999 68, 2069-2073DOI: (10.1016/S0003-4975(99)01064-4)

Fig 2 (A) Postoperative overall survival among all the patients (n = 206). (B) Postoperative disease-free survival (DFS) among the patients undergoing potentially curative operation (n = 190). The groups with less of a BAC component showed a significantly worse prognosis (overall survival, p = 0.0009; DFS, p < 0.0001). The Annals of Thoracic Surgery 1999 68, 2069-2073DOI: (10.1016/S0003-4975(99)01064-4)

Fig 3 (A) Postoperative overall survival among the patients with stage I disease (n = 151). (B) Postoperative disease-free survival (DFS) among the stage I patients undergoing potentially curative operation (n = 149). Type II patients showed a significantly worst prognosis (overall survival, p = 0.0007; DFS, p < 0.0001). In contrast, type I patients showed rather the same prognosis as type III patients. The Annals of Thoracic Surgery 1999 68, 2069-2073DOI: (10.1016/S0003-4975(99)01064-4)