Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease  Raj Vuppalanchi, Ajay K. Jain, Ross Deppe, Katherine Yates, Megan Comerford, Howard C. Masuoka, Brent A. Neuschwander-Tetri, Rohit Loomba, Elizabeth M. Brunt, David E. Kleiner, Jean P. Molleston, Jeffrey B. Schwimmer, Joel E. Lavine, James Tonascia, Naga Chalasani  Clinical Gastroenterology and Hepatology  Volume 12, Issue 12, Pages 2121-2130.e2 (December 2014) DOI: 10.1016/j.cgh.2014.05.010 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Changes in serum K18 levels in the PIVENS trial. (A) Changes in serum K18 levels in 3 treatment groups (placebo, pioglitazone, and vitamin E) during the PIVENS trial. (B) Changes in serum K18 levels in adults who achieved histologic improvement compared with those who did not achieve histologic improvement in the PIVENS trial. Histologic improvement was defined based on specified change in NAS and no progression of fibrosis, as described in the text. (C) Changes in serum K18 levels in adults with and without resolution of NASH in the PIVENS trial. Clinical Gastroenterology and Hepatology 2014 12, 2121-2130.e2DOI: (10.1016/j.cgh.2014.05.010) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Changes in serum K18 fragment levels during the TONIC trial. (A) Changes in serum K18 levels in the 3 treatment groups (placebo, metformin, and vitamin E) during the TONIC trial. (B) Changes in serum K18 levels in adults who achieved histologic improvement compared with those who did not achieve histologic improvement in the TONIC trial. Histologic improvement was defined based on change in NAS and no progression of fibrosis, as described in the text. (C) Changes in serum K18 levels in adults with and without resolution of NASH in the TONIC trial. Clinical Gastroenterology and Hepatology 2014 12, 2121-2130.e2DOI: (10.1016/j.cgh.2014.05.010) Copyright © 2014 AGA Institute Terms and Conditions