Volume 4, Issue 1, Pages (July 2001)

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Volume 4, Issue 1, Pages 52-57 (July 2001) Effects of Linear Polyethylenimine and Polyethylenimine/DNA on Lung Function after Airway Instillation to Rat Lungs Aima N. Uduehi, Uz Stammberger, Bartosz Kubisa, Matthias Gugger, Thomas A. Buehler, Ralph A. Schmid Molecular Therapy Volume 4, Issue 1, Pages 52-57 (July 2001) DOI: 10.1006/mthe.2001.0413 Copyright © 2001 American Society for Gene Therapy Terms and Conditions

Fig. 1 Luciferase expression in rat lungs 24 h and 72 h after instillation of naked DNA or DNA/PEI. Data represent the mean ± SEM. *P < 0.0001 compared with DNA/PEI 24 h. Molecular Therapy 2001 4, 52-57DOI: (10.1006/mthe.2001.0413) Copyright © 2001 American Society for Gene Therapy Terms and Conditions

Fig. 2 Gas exchange of the transfected left lung after exclusion of the right lung 24 h (A) or 72 h (B) after instillation of glucose, naked DNA, DNA/PEI, or PEI. Data represent the mean ± SEM. *P < 0.0001 compared with rats treated with naked DNA. Molecular Therapy 2001 4, 52-57DOI: (10.1006/mthe.2001.0413) Copyright © 2001 American Society for Gene Therapy Terms and Conditions

Fig. 3 Histological findings in rat lungs 24 h (A–F) or 72 h (G–N) after instillation of glucose (A, B, G, H), naked DNA (C, D, I, J), DNA/PEI (E, F, K, L), or PEI (M, N). Sections were cut to 3 thick and stained with hematoxylin and eosin. Magnification, x100. Molecular Therapy 2001 4, 52-57DOI: (10.1006/mthe.2001.0413) Copyright © 2001 American Society for Gene Therapy Terms and Conditions