Michelle R. Zeidler, MD, MS, Jonathan G. Goldin, MD, PhD, Eric C

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Small airways response to naturalistic cat allergen exposure in subjects with asthma Michelle R. Zeidler, MD, MS, Jonathan G. Goldin, MD, PhD, Eric C. Kleerup, MD, Hyun J. Kim, MS, Dao A. Truong, BS, David W. Gjertson, PhD, Nola J. Kennedy, PhD, Kenneth B. Newman, MD, Donald P. Tashkin, MD, Jeffrey M. Silverman, MD, Jonathan Corren, MD Journal of Allergy and Clinical Immunology Volume 118, Issue 5, Pages 1075-1081 (November 2006) DOI: 10.1016/j.jaci.2006.06.042 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Study timeline. PFT, Pulmonary function test, including CV. Journal of Allergy and Clinical Immunology 2006 118, 1075-1081DOI: (10.1016/j.jaci.2006.06.042) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 HRCT data analysis. A, The acquisition of 12 regions of interest consisting of right rostral, right caudal, left rostral, and left caudal, each subdivided into ventral (nondependent), intermediate, and dorsal (dependent) sections. A lung attenuation curve is then derived for each regions of interest. B, A representative lung attenuation curve. Reproduced with permission from Zeidler MR, Goldin J, Kleerup EC, Truong D, Simmons M, Kim HJ, et al. Montelukast improves regional air-trapping due to small airways obstruction in asthma. Eur Respir J 2006;27:307-15.15 Journal of Allergy and Clinical Immunology 2006 118, 1075-1081DOI: (10.1016/j.jaci.2006.06.042) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Time course of changes in FEF25-75 (A) and FEV1 (B) at baseline, CRC, and recovery. Journal of Allergy and Clinical Immunology 2006 118, 1075-1081DOI: (10.1016/j.jaci.2006.06.042) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Representative lung attenuation curves at baseline and 6 hours and 23 hours after CRC. Journal of Allergy and Clinical Immunology 2006 118, 1075-1081DOI: (10.1016/j.jaci.2006.06.042) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Representative images at PM baseline (A), AM baseline (B), and 6 (C) and 23 hours (D) after CRC. Journal of Allergy and Clinical Immunology 2006 118, 1075-1081DOI: (10.1016/j.jaci.2006.06.042) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions