Golgi Feels DNA’s Pain Cell

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Golgi Feels DNA’s Pain Cell Marco Foiani, Jiri Bartek Cell Volume 156, Issue 3, Pages 392-393 (January 2014) DOI: 10.1016/j.cell.2014.01.030 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 DNA-PK-Mediated Golgi Regulation in Response to DNA Damage Chromatin is physically connected to the nuclear envelope, which is continuous with the endoplasmic reticulum (ER). Membrane contact sites connect the ER with the Golgi apparatus and with the plasma membrane. GOLPH3 (dark blue shape) is attached to actin (black lines). DNA double-strand breaks generate a signal (red dot) leading to GOLPH3 phosphorylation through a process (arrow) mediated by DNA-PK, inducing Golgi dispersal, impaired intracellular trafficking, and enhanced cell survival. The zoomed-in area depicts DNA-PK-mediated phosphorylation of the critical T143/T148 residues of GOLPH3. Cell 2014 156, 392-393DOI: (10.1016/j.cell.2014.01.030) Copyright © 2014 Elsevier Inc. Terms and Conditions