Fig. 5. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative chimpanzees. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative.

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Fig. 5. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative chimpanzees. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative chimpanzees. Total RNA isolated from the liver biopsies after the NUC lead-in and before ARC-520 dosing on day 1 from HBeAg-positive chimpanzee A2A004 and HBeAg-negative chimpanzee 88A010 was reverse-transcribed, size-selected, and sequenced with SMRT sequencing. (A) Full-length nonconcatemer reads were aligned to each chimpanzee’s consensus HBV DNA sequence. Green lines represent HBV-containing transcripts. Dark green represents sequences aligning to HBV, and light green represents those not aligning to HBV. The HBV coordinates are shown with elements DR2, DR1, and the HBV PAS. (B) Cumulative fraction of HBV-chimpanzee breakpoints was plotted against the HBV coordinate. Christine I. Wooddell et al., Sci Transl Med 2017;9:eaan0241 Published by AAAS