Cell Migration: A Physically Integrated Molecular Process

Slides:



Advertisements
Similar presentations
Rho family GTPases Thuy Nguyen 3/6/2012
Advertisements

Introduction Cell migration is critical in many biological processes including foetal development, wound healing and the immune response. However, occasionally.
Interactions Between Cells and Their Environment
Cell Motility and Shape require microfilaments (F-actin), microtubules and intermediate filaments. Not surprisingly, the actin skeleton is dynamic, not.
SIGNAL PATHWAYS IN CELL MIGRATION AND ADHESION Sam Polak 28 April 2008.
Lecture 12 - The actin cytoskeleton
Lecture 17 - Cell motility. The Range of Cell Movement Velocities of moving cells span more than 4 orders of magnitude Each cell has evolved.
Bio 178 Lecture 10 Cell Structure (Cntd.) Copyright: E.G. Platzer.
Lecture 12 - The actin cytoskeleton. Actin filaments allow cells to adopt different shapes and perform different functions VilliContractile bundles.
Copyright (c) by W. H. Freeman and Company Chapter 18 Cell Motility and Shape I: Microfilaments.
Actin By Enrique M. De La Cruz & E. Michael Ostap
Transport Processes Passive processes Active processes
Cell Signaling and Migration Erich Lidstone April 29, 2009.
Cell Migration Tom Paine March 16, Will cover papers on single cell migration, adhesion- dependent trafficking and collective cell migration. Single.
Lecture 3 Actin and myosin in non-muscle cells; Cell motility Outline:
Copyright © 2005 Pearson Prentice Hall, Inc.
Tissue dynamic and Morphogenesis Dept. Physiology Chang Gung University J. K. Chen, Professor.
LECTURE 3 - NONMUSCLE CELLS & CELL LOCOMOTION Non-Contractile Bundles Lamellipodia Filopodia Surface Projections Non-Muscle Cells Circumferential belt.
Last Class 1. GPCR signaling: 2. Enzyme-linked Receptor signaling:
The Muscular System PP # 3 Contraction
The Cytoskeleton الهيكل الخلوي
Fundamentals of Biological Sciences
NOTES: The Muscular System (Ch 8, part 2)
Listeria Cycle of Propagation
درس دوم اسکلت سلولی و ضمائم تحرک سلول ها
Moving Membrane up to the Front of Migrating Cells
The Sliding-Filament Mechanism
Guang-Kui Xu, Xi-Qiao Feng, Huajian Gao  Biophysical Journal 
Actin and Microtubules: Working Together to Control Spindle Polarity
Cell Migration: PKA and RhoA Set the Pace
Cell migration Current Biology
Volume 20, Issue 12, Pages R525-R527 (June 2010)
Lamellipodial extension driven by actin assembly
Cell Migration, Freshly Squeezed
Actin Dynamics: Growth from Dendritic Branches
Spatial Control of Actin Filament Assembly
Endocytic Trafficking of Integrins in Cell Migration
Stresses at the Cell Surface during Animal Cell Morphogenesis
Eric A. Vitriol, James Q. Zheng  Neuron 
Volume 93, Issue 3, Pages (March 2018)
Lino Ferreira, Jeffrey M. Karp, Luis Nobre, Robert Langer 
Coordinating Neuronal Actin–Microtubule Dynamics
Nuclear Mechanics and Mechanotransduction in Health and Disease
Intracellular Motility: Myosin and Tropomyosin in Actin Cable Flow
Steroid hormones: Interactions with membrane-bound receptors
Actin Waves: Origin of Cell Polarization and Migration?
Eric A. Vitriol, James Q. Zheng  Neuron 
Inês Mendes Pinto, Boris Rubinstein, Rong Li  Biophysical Journal 
Quantitative Imaging Approaches to Study the CAR Immunological Synapse
Cell Movement Is Guided by the Rigidity of the Substrate
Volume 107, Issue 11, Pages (December 2014)
The mechanical cell Current Biology
Bacterial Gliding Motility: Rolling Out a Consensus Model
Bidirectional Transport along Microtubules
Forcing contact inhibition of locomotion
Computer Vision in Cell Biology
Sarah L. Lebeis, Daniel Kalman  Cell Host & Microbe 
Exploring the Neighborhood
Deanna M Koepp, Pamela A Silver  Cell 
Dynamic Analysis of Dorsal Closure in Drosophila
Volume 84, Issue 3, Pages (February 1996)
Actin-Based Cell Motility and Cell Locomotion
Two Poles and a Compass Cell
Cell migration is mediated by Rho-GTPase protein activity.
Three Functions of Cadherins in Cell Adhesion
Ras and Rho GTPases Cell
A new key in breast cancer metastasis
Polymer Motors: Pushing out the Front and Pulling up the Back
Neurons Take Shape Current Biology
Volume 20, Issue 1, Pages 9-18 (January 2011)
Presentation transcript:

Cell Migration: A Physically Integrated Molecular Process Douglas A Lauffenburger, Alan F Horwitz  Cell  Volume 84, Issue 3, Pages 359-369 (February 1996) DOI: 10.1016/S0092-8674(00)81280-5

Figure 1 Illustration of Different Forces Involved in Cell Migration Protrusion of membrane lamellipodia or filopodia requires force generated by actin polymerization, by the Brownian ratchet mechanism, the cortical expansion mechanism, or a combination of these. Translocation of the cell body forward, once the membrane protrusion has become adherent to the substratum, may occur by myosin interactions with actin filaments; possible mechanisms for this include contraction of filaments connecting cell–substratum adhesion complexes with intracellular structures, or relative movement of adhesion complexes across cortical actin filament “tracks.” In either case, the magnitude of traction is greater than the rearward pull on the adhesion complexes. Detachment of the cell rear involves disruption of cell– substratum attachments, perhaps accelerated by myosin-mediated actin filament contraction pulling on adhesion complexes. Here, the magnitude of traction is less than the contraction force. Cell 1996 84, 359-369DOI: (10.1016/S0092-8674(00)81280-5)

Figure 2 Illustration of Integrin Adhesion Receptor Dynamics in Cell Migration Newly synthesized or recycled integrins may be inserted into the plasma membrane behind the leading lamella, then transported to the edge by diffusion and directed transport (possibly mediated by myosin I actions). Once there, adhesion bonds are formed with substratum ligands, followed by nascent aggregates—adhesion complexes—which grow as the cell moves forward. At the rear of the cell, these adhesions are released as the trailing edge detaches from the substratum. Their integrin contents may be extracted from the membrane and left behind on the substratum, or dispersed by diffusion on the membrane surface, or internalized. The aggregates may also move along the edge of the migrating cell for a while before being eventually disrupted. Cell 1996 84, 359-369DOI: (10.1016/S0092-8674(00)81280-5)

Figure 3 Components Implicated in Cell Migration Compilation of regulatory and effector components apparently implicated in cell migration mechanisms of membrane protrusion and attachment to the substratum, and release of the cell rear followed by retraction of the tail. Cell 1996 84, 359-369DOI: (10.1016/S0092-8674(00)81280-5)