High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient Theoharis C. Theoharides,

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Presentation transcript:

High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient Theoharis C. Theoharides, MS, PhD, MD, Anastasia I. Petra, MD, Julia M. Stewart, RN, Irene Tsilioni, PhD, Smaro Panagiotidou, MA, Cem Akin, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 5, Pages 1197-1199 (November 2014) DOI: 10.1016/j.jaci.2014.05.023 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Photograph of the chest of this patient showing contact/pressure dermatitis at the sites of the adhesive lead placement 6 hours after electrocardiography monitoring (Fig 1, A); photograph of her left leg showing one urticaria pigmentosa lesion (Fig 1, B, within the rectangular box). Journal of Allergy and Clinical Immunology 2014 134, 1197-1199DOI: (10.1016/j.jaci.2014.05.023) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Photomicrograph (Fig 2, A) of a BM biopsy from this patient showing clusters of MC (solid arrow) and some degranulated MC (open arrow). The insert (red rectangle) shows 2 MC with positive CRHR-1 fluorescent staining (green). The slide was deparaffinized and reprobed with a fluorescent-tagged polyclonal goat anti-human CRHR-1 antibody (V-14-sc-12381, Santa Cruz, Calif); staining with a nonspecific anti-IgG antibody produced no fluorescent staining. Fluorescence-activated cell sorting analysis (Fig 2, B) of human umbilical cord blood–derived cultured MC. The x axis corresponds to FITC-conjugated c-kit, and the y axis corresponds to phycoerythrin-conjugated CRHR-1. The cells labeled in quadrant R3/R7 (box) are positive for both c-kit and CRHR-1; the insert shows 2 such fluorescent cells. Quadrant R5 shows nonspecific fluorescence. Journal of Allergy and Clinical Immunology 2014 134, 1197-1199DOI: (10.1016/j.jaci.2014.05.023) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions