Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study Elizabeth Temkin,

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Presentation transcript:

Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study Elizabeth Temkin, DrPH, Noga Fallach, MA, Jonatan Almagor, PhD, Beryl Primrose Gladstone, PhD, Prof Evelina Tacconelli, MD, Prof Yehuda Carmeli, MD The Lancet Global Health Volume 6, Issue 9, Pages e969-e979 (September 2018) DOI: 10.1016/S2214-109X(18)30278-X Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 1 Conceptual overview of the data analysis method 3GC=third-generation cephalosporin. The Lancet Global Health 2018 6, e969-e979DOI: (10.1016/S2214-109X(18)30278-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 2 Annual incidence of serious infections caused by antibiotic-susceptible Escherichia coli and Klebsiella pneumoniae in 17 countries Black solid lines are the weighted means; green lines are 1 SE and blue lines are 2 SEs from the weighted means. (A) Third-generation cephalosporin-susceptible E coli. (B) Carbapenem-susceptible E coli. (C) Third-generation cephalosporin-susceptible K pneumoniae. (D) Carbapenem-susceptible K pneumoniae. The Lancet Global Health 2018 6, e969-e979DOI: (10.1016/S2214-109X(18)30278-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 3 Estimated incidence of serious infections caused by third-generation cephalosporin-resistant Escherichia coli with the various models In the combination models, replacement begins once the level of resistance is greater than 30%. The Lancet Global Health 2018 6, e969-e979DOI: (10.1016/S2214-109X(18)30278-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions