K.D. Novakofski, R.M. Williams, L.J. Bonassar, L.A. Fortier

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Presentation transcript:

Early cartilage injury quantified and characterized with multiphoton microscopy imaging K.D. Novakofski, R.M. Williams, L.J. Bonassar, L.A. Fortier Osteoarthritis and Cartilage Volume 21, Pages S182-S183 (April 2013) DOI: 10.1016/j.joca.2013.02.388 Copyright © 2013 Terms and Conditions

Figure 1 MPM of control and injured samples. Control samples typically contained few fluorescein-stained cells, while injured samples typically contained fluorescein-stained cells, autofluorescent structures, and cracks. Osteoarthritis and Cartilage 2013 21, S182-S183DOI: (10.1016/j.joca.2013.02.388) Copyright © 2013 Terms and Conditions

Figure 2 3-D reconstruction of control and injured cartilage from n=1 sample. Each point represents a single dead chondrocyte. The total volume scanned was a checkerboard of volumetric Z-scans, with 10 images at 10 μm-step intervals. An image such as that in Figure 1 represents 1.6% of the area in Figure 2. Osteoarthritis and Cartilage 2013 21, S182-S183DOI: (10.1016/j.joca.2013.02.388) Copyright © 2013 Terms and Conditions