Cellular and Systems Reconsolidation in the Hippocampus

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Cellular and Systems Reconsolidation in the Hippocampus Jacek Debiec, Joseph E LeDoux, Karim Nader  Neuron  Volume 36, Issue 3, Pages 527-538 (October 2002) DOI: 10.1016/S0896-6273(02)01001-2

Figure 1 Hippocampal-Mediated Memories Undergo Protein Synthesis-Dependent Reconsolidation (A–B) Schematic of the procedure used with the data presented below. Vertical open-headed arrows represent infusions. (A) Anisomycin infusions impaired PR-LTM, but not PR-STM. (B) Omitting memory reactivation protected the memory from being lost. This procedure was identical to (A) except that the contextual memory was not reactivated. Instead, animals were taken to a different room and given the infusions. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)

Figure 2 The Effects of Anisomycin Are Specific to the Hippocampus and Do Not Support Conditioned Competing Responses (A) Anisomycin's effects are due to an action within the hippocampus. Intraventricular (ICV) infusions of anisomycin had no effects on reconsolidation. (B) Anisomycin does not act as a US after fear expression to mediate conditioned responses that could compete with freezing. The CS is the context. The tone is a previously fear-conditioned tone that was presented for the duration of the preexposure period. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)

Figure 3 Increasing the Training-Reactivation Delay Has No Effect on the Memory's Ability to Return to a Labile State Intra-hippocampus anisomycin blocks reconsolidation after memory reactivation (A) 15 or (B) 45 days after training. In both cases, a specific effect was found on PR-LTM, but not PR-STM. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)

Figure 4 Reconsolidation Does Not Show a Temporally Graded Retrograde Amnesic Gradient A memory index was computed for groups in the 3, 15, and 45 day experiment (PR-LTM/PR-STM %). Because the PR-STM test produces approximately 20% extinction, the controls lie at approximately 75%–80%. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)

Figure 5 Hippocampal Memories Undergo Systems Reconsolidation (A–B) Schematic of the procedure used with the data presented below. (A) Remote hippocampus-independent memories return to being hippocampus dependent after memory reactivation. The score of the CS/lesion group did not show any spontaneous recovery across all test days. The no CS/sham and no CS/lesion group did not significantly differ as there was no significant interaction between group and test days. (B) The hippocampus plays a time-limited role in the restabilization of a reactivated remote memory. This second temporally graded retrograde amnesic gradient was only 2 days after which time the trace once again became hippocampus independent. (C) Retesting animals in the 4 hr group weekly for up to 28 days did not cause any spontaneous recovery. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)

Figure 6 Contextual Memories Return to a State of Hippocampus Dependence for a Third Time Top shows a schematic of the procedure used with the data presented below. Fourty-five days after conditioning, a time when the first temporally graded retrograde amnesic gradient is complete and the contextual memory has become hippocampus independent, the memory was reactivated. Two days later, when the second retrograde gradient was complete and the memory was once again hippocampus independent, the memory was reactivated again, and animals received sham or electrolytic lesions of the dorsal hippocampus. Animals that received lesions immediately, but not 48 hr, after reactivation showed a deficit in contextual freezing. Thus, the duration of the third retrograde gradient is comparable to the second. Neuron 2002 36, 527-538DOI: (10.1016/S0896-6273(02)01001-2)