Favorable Outcome in Patients with Acute Myelogenous Leukemia with the Nucleophosmin Gene Mutation Autografted after Conditioning with High-Dose Continuous.

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Favorable Outcome in Patients with Acute Myelogenous Leukemia with the Nucleophosmin Gene Mutation Autografted after Conditioning with High-Dose Continuous Infusion of Idarubicin and Busulfan Felicetto Ferrara, Tiziana Izzo, Clelia Criscuolo, Cira Riccardi, Giada Muccioli, Assunta Viola, Fabrizio Pane, Salvatore Palmieri Biology of Blood and Marrow Transplantation Volume 16, Issue 7, Pages 1018-1024 (July 2010) DOI: 10.1016/j.bbmt.2010.02.011 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 OS and DSF for the whole patient population (median: 34 and 22 months, respectively). Biology of Blood and Marrow Transplantation 2010 16, 1018-1024DOI: (10.1016/j.bbmt.2010.02.011) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 OS and DFS of patients with NPM1 isolated mutations as opposed to controls: median OS and DFS were significantly longer for patients with isolated NPM1 mutation as opposed to controls (OS: not reached versus 25 months, P = .02; DFS: not reached versus 16 months, P = .007, respectively). Biology of Blood and Marrow Transplantation 2010 16, 1018-1024DOI: (10.1016/j.bbmt.2010.02.011) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 OS and DFS of patients with NPM1 isolated mutations as opposed to patients with NPM1+/FLT3+ AML (median OS not reached versus 27 months, P = .03; DFS not reached versus 16 months, P = .004). Biology of Blood and Marrow Transplantation 2010 16, 1018-1024DOI: (10.1016/j.bbmt.2010.02.011) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions