Parathyroid disease and calcium metabolism

Slides:

Advertisements

Similar presentations

Inverse sigmoidal relationship between parathyroid hormone (PTH) release and the extracellular calcium concentration in human studies (upper panel) and.

Advertisements

Human Keratinocytes Express Multiple P2Y-Receptors: Evidence for Functional P2Y1, P2Y2, and P2Y4 Receptors Helen E. Burrell, Wayne B. Bowler, James A.

Altered Calcium-Mediated Cell Signaling in Keratinocytes Cultured from Patients with Neurofibromatosis Type 1 Timo Korkiamäki, Heli Ylä-Outinen, Jussi.

Switching Heterotrimeric G Protein Subunits with a Chemical Dimerizer

Temporal Bias: Time-Encoded Dynamic GPCR Signaling

Patrick Delmas, Bertrand Coste, Nikita Gamper, Mark S. Shapiro Neuron

Jean-Yves Chatton, Yumei Cao, Jörg W. Stucki Biophysical Journal

Nathan R. Tykocki, PhD, BinXi Wu, BS, William F

Preventing surgical deaths: critical care and intensive care outreach services in the postoperative period D.R. Goldhill British Journal of Anaesthesia

Insulin Secretion: Fatty Acid Signalling via Serpentine Receptors

Mg2+ dependence of Ca2+ release from the sarcoplasmic reticulum induced by sevoflurane or halothane in skeletal muscle from humans susceptible to malignant.

Caveolae and propofol effects on airway smooth muscle

Volume 53, Issue 5, Pages (May 1998)

Role of proton gradients and vacuolar H+-ATPases in the refilling of intracellular calcium stores in exocrine cells C. Camello, J.A. Pariente, G.M. Salido,

Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients

Calcium-Dependent Facilitation and Graded Deactivation of Store-Operated Calcium Entry in Fetal Skeletal Muscle Claude Collet, Jianjie Ma Biophysical.

Pain in cancer survivors; filling in the gaps

Presence of store-operated Ca2+ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane A. Kojima, H. Kitagawa, M. Omatsu-Kanbe,

Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca2+i Mobilization and NFAT2 Activation Ralph Jans, Laura Mottram, Darren.

Supplemental oxygen and surgical site infection: getting to the truth

Etienne Roux, Marko Marhl Biophysical Journal

α1-Adrenoceptor Subtype Selectivity and Lower Urinary Tract Symptoms

Sahba Fatherazi, Carol M. Belton, Kenneth T. Izutsu

Heat stroke: implications for critical care and anaesthesia

L. Figueroa, N. Kraeva, C. Manno, S. Toro, E. Ríos, S. Riazi

Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis N. Hussain, C.J.L. McCartney, J.M. Neal, J.

Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality.

Intestinal Stem Cells: Got Calcium?

Mark S Taylor, A.Marie McMahon, Jason D Gardner, Joseph N Benoit

Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies C.P.R. Walker, D. Royston

The effects of general anaesthetics on ligand-gated ion channels

Calcium Signals Tune the Fidelity of Transcriptional Responses

Lysophospholipid Receptor-Mediated Calcium Signaling in Human Keratinocytes Karin Lichte, Roberto Rossi, Kerstin Danneberg, Michael ter Braak, Ulrich.

Graphic Interpretation of Serum Parathyroid Hormone, Calcium, and Phosphorus Values in Primary Hyperparathyroidism Pai C. Kao, Ph.D., Edward G. Lufkin,

Codeine phosphate in paediatric medicine

Volume 55, Issue 4, Pages (April 1999)

Let's look at cysts from both sides now

SERCA2 Dysfunction in Darier Disease Causes Endoplasmic Reticulum Stress and Impaired Cell-to-Cell Adhesion Strength: Rescue by Miglustat Magali Savignac,

Neuromuscular junction in health and disease

Pituitary disease and anaesthesia

On Imposing Detailed Balance in Complex Reaction Mechanisms

Anaesthetic modulation of synaptic transmission in the mammalian CNS

Bispectral analysis of the electroencephalogram does not predict responsiveness to verbal command in patients emerging from xenon anaesthesia† T. Goto,

Chia-Ling Tu, Wenhan Chang, Daniel D. Bikle

Temporal Bias: Time-Encoded Dynamic GPCR Signaling

Heme oxygenase: protective enzyme or portal hypertensive molecule?

SERCA2-Controlled Ca2+-Dependent Keratinocyte Adhesion and Differentiation Is Mediated via the Sphingolipid Pathway: A Therapeutic Target for Darier's.

Volume 18, Issue 3, Pages (January 2017)

Preoperative evaluation of patients with, or at risk of, coronary artery disease undergoing non-cardiac surgery P.-G. Chassot, A. Delabays, D.R. Spahn

Pain and the immune system

Complex regional pain syndrome

Volume 99, Issue 8, Pages (October 2010)

PtdIns-3,4,5-P3 Cell Volume 94, Issue 1, Pages 5-8 (July 1998)

Editorial II British Journal of Anaesthesia

Developments in local anaesthetic drugs

Volume 99, Issue 8, Pages (October 2010)

J Lee, S Gupta, C Price, A.P. Baranowski

Volume 77, Issue 6, Pages (March 2010)

General scheme of intracellular Ca2+ cycling.

D-type prostanoid receptor enhances the signaling of chemoattractant receptor– homologous molecule expressed on TH2 cells Miriam Sedej, MSc, Ralf Schröder,

Targeting TNF-α: A novel therapeutic approach for asthma

Diffusion of nitrous oxide into the pleural cavity†

Human Leukocyte Elastase Induces Keratinocyte Proliferation by Epidermal Growth Factor Receptor Activation Ulf Meyer-Hoffert, Jana Wingertszahn, Oliver.

Inositol Trisphosphate and Cyclic ADP-Ribose–Mediated Release of Ca2+ from Single Isolated Pancreatic Zymogen Granules Oleg V Gerasimenko, Julia V Gerasimenko,

Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm J.A. Alhashemi British Journal of Anaesthesia

Editorial II British Journal of Anaesthesia

Aluminum is a weak agonist for the calcium-sensing receptor

Linking Calcium to Aβ and Alzheimer's Disease

Annexin 5 mediates a peroxide-induced Ca2+ influx in B cells

Shuai Zeng, Bing Li, Shaoqun Zeng, Shangbin Chen Biophysical Journal

Presentation transcript:

Parathyroid disease and calcium metabolism R. Mihai, J.R. Farndon British Journal of Anaesthesia Volume 85, Issue 1, Pages 29-43 (July 2000) DOI: 10.1093/bja/85.1.29 Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 1 (1) Schematic representation of the Ca2+ receptor's signalling mechanisms. Ca2+ receptor agonists bind to the extracellular domain of the Ca2+ receptor and trigger activation of the G protein–phospholipase C (PLC) pathway. PLC generates inositol-trisphosphate (IP3), which binds to specific receptors situated on intracellular Ca2+ stores. Upon binding of IP3 the three-dimensional structure of IP3 receptors changes and allows the release of Ca2+. The responsiveness of IP3 receptors modulates the amplitude of [Ca2+]i responses following activation of the Ca2+ receptor.63 The filling state of the intracellular Ca2+ stores is maintained by the action of specific Ca2+ pumps, i.e. the smooth endoplasmic reticulum Ca2+-ATPases (SERCA). (2) The graphs illustrate changes in cytoplasmic concentration of calcium ([Ca2+]i) in parathyroid cells. [Ca2+]i was measured using quantitative fluorescent microscopy in Fura-2-loaded cells. The upper panel illustrates responses to changes in [Ca2+]ext from 0.5 to 3 mM. The lower panel illustrates [Ca2+]i responses to the Ca2+ receptor agonist lanthanum (La3+; 15 μM). (3) [Ca2+]i increases rapidly following incubation with thapsigargin, an inhibitor of SERCA. British Journal of Anaesthesia 2000 85, 29-43DOI: (10.1093/bja/85.1.29) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 2 Lack of correlation between the weight of parathyroid adenomas and the biochemical abnormalities. In 37 patients with primary hyperparathyroidism, the weight of parathyroid adenomas was determined immediately after surgical removal. Preoperative values for calcium (corrected for albumin concentration) and PTH were recorded. Intact PTH (1–84) was measured using a chemiluminescent assay (Immulite, DPC, Gwynedd, UK; coefficient of variance 4.7% and 5.5% for intrassay and interassay precision, respectively). British Journal of Anaesthesia 2000 85, 29-43DOI: (10.1093/bja/85.1.29) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions