Volume 125, Issue 5, Pages (November 2003)

Slides:

Advertisements

Similar presentations

Genetic testing for high-risk colon cancer patients1 William M. Grady Gastroenterology Volume 124, Issue 6, Pages (May 2003) DOI: /S (03)

Advertisements

Volume 65, Issue 6, Pages (June 2004)

Volume 59, Issue 3, Pages (March 2001)

Volume 117, Issue 1, Pages (July 1999)

Volume 84, Issue 1, Pages (July 2013)

Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct– ligated rats Hongqun Liu, Zenghua Ma, Samuel S. Lee Gastroenterology

Loss of renal function and microvascular blood flow after suprarenal aortic clamping and reperfusion (SPACR) above the superior mesenteric artery is greatly.

Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Postoperative Ileus Beverley A. Moore, Carl L. Manthey,

Vein wall re-endothelialization after deep vein thrombosis is improved with low- molecular-weight heparin Daria K. Moaveni, MD, Erin M. Lynch, MS, Cathy.

Volume 117, Issue 5, Pages (November 1999)

Volume 53, Issue 3, Pages (September 2010)

Cyril H. Barton, Zehnmin Ni, Nosratola D. Vaziri Kidney International

Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension Don C. Rockey, John J. Chung

Long-acting oral phosphodiesterase inhibition preconditions against reperfusion injury in an experimental lung transplantation model Eric S. Weiss, MD,

Volume 138, Issue 4, Pages (April 2010)

Vasoconstrictor Therapy for the Hepatorenal Syndrome

Volume 145, Issue 4, Pages e5 (October 2013)

Volume 127, Issue 4, Pages (October 2004)

Volume 116, Issue 2, Pages (February 1999)

Volume 62, Issue 2, Pages (August 2002)

Volume 59, Issue 3, Pages (March 2001)

Volume 132, Issue 1, Pages (January 2007)

Volume 118, Issue 4, Pages (April 2000)

Physical exercise reduces transplant arteriosclerosis in a mouse aorta transplantation model Wiebke Sommer, MD, Ann-Kathrin Knöfel, PhD, Nicole Izykowski,

Volume 126, Issue 3, Pages (March 2004)

Volume 66, Issue 6, Pages (December 2004)

Volume 65, Issue 6, Pages (June 2004)

Covering the Cover Gastroenterology

Volume 84, Issue 1, Pages (July 2013)

Christopher A. Ward, Hongqun Liu, Samuel S. Lee Gastroenterology

Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Postoperative Ileus Beverley A. Moore, Carl L. Manthey,

Ambient pressure upregulates nitric oxide synthase in a phosphorylated-extracellular regulated kinase– and protein kinase C–dependent manner Angela G.

Volume 117, Issue 5, Pages (November 1999)

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target.

Stuart I. Myers, MD, Li Wang, BS, Fang Liu, BS, Lori L. Bartula, BS

Single-dose rosuvastatin ameliorates lung ischemia–reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage.

Nosratola D. Vaziri, Kaihui Liang, Yaoxian Ding Kidney International

Volume 130, Issue 3, Pages (March 2006)

The Zinc Transporter Zip14 Influences c-Met Phosphorylation and Hepatocyte Proliferation During Liver Regeneration in Mice Tolunay Beker Aydemir, Harry.

Volume 118, Issue 2, Pages (February 2000)

Volume 67, Issue 3, Pages (March 2005)

Inducible nitric oxide synthase (iNOS), early growth response protein 2 (Erg2) and podoplanin expression on in vitro-generated inflammatory alveolar macrophages.

Volume 75, Issue 2, Pages (January 2009)

Volume 124, Issue 5, Pages (May 2003)

Volume 132, Issue 2, Pages (February 2007)

A New Treatment for Portal Hypertension?

Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat C. David Mazer, MD, Francoise.

Reduced adenosine A2a receptor–mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration Patrik Persson, Peter.

Covering the Cover Gastroenterology

Differential Regulation of Cyclooxygenase-2 Expression by Phytosphingosine Derivatives, NAPS and TAPS, and its Role in the NAPS or TAPS-Mediated Apoptosis

Volume 74, Issue 1, Pages (July 2008)

Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis Sandra Pfister, PhD, Lewis Somberg,

Volume 70, Issue 1, Pages (July 2006)

Volume 60, Issue 6, Pages (December 2001)

Volume 119, Issue 1, Pages (July 2000)

Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease Shen Xiao, Laszlo Wagner, Rebecca J. Schmidt,

Volume 60, Issue 1, Pages (July 2001)

Volume 68, Issue 6, Pages (December 2005)

Reiner Wiest, Ming–Hung Tsai, Roberto J. Groszmann Gastroenterology

A Novel Role for the Fibroblast Growth Factor 21 in Acute Pancreatitis

Overexpression of endothelial nitric oxide synthase increases skeletal muscle blood flow and oxygenation in severe rat hind limb ischemia Lucy S Brevetti,

Loss of renal function and microvascular blood flow after suprarenal aortic clamping and reperfusion (SPACR) above the superior mesenteric artery is greatly.

Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection Nancy C. Moss, MD, Ru-Hang Tang, PhD, Monte.

Suprarenal aortic clamping and reperfusion decreases medullary and cortical blood flow by decreased endogenous renal nitric oxide and PGE2 synthesis

Chronic digitalis administration alters mesenteric vascular reactivity

Volume 57, Issue 6, Pages (June 2000)

Volume 61, Issue 3, Pages (March 2002)

Volume 57, Issue 1, Pages (January 2000)

Volume 61, Issue 4, Pages (April 2002)

Nitric Oxide in Endothelial Dysfunction and Vascular Remodeling: Clinical Correlates and Experimental Links Radu D. Rudic, William C. Sessa The American.

Presentation transcript:

Volume 125, Issue 5, Pages 1452-1461 (November 2003) Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats Ming-Hung Tsai, Yasuko Iwakiri, Gregory Cadelina, William C Sessa, Roberto J Groszmann Gastroenterology Volume 125, Issue 5, Pages 1452-1461 (November 2003) DOI: 10.1016/j.gastro.2003.07.014

Figure 1 The perfusion pressure changes in response to methoxamine in isolated mesenteric arterial beds at different times. (A) The vasopressor responses of the PVL-20G animals were compared with the sham-operated animals at different times. n = 5–8 per group per each time point. ∗P < 0.01, #P < 0.001 compared with the corresponding sham rats. (B) The vasopressor responses to methoxamine after NOS inhibitor (l-NMMA) treatment in the isolated SMA beds. n = 4–6 per group per each time point. MTx30, methoxamine 30 μmol/L; MTx100, 100 μmol/L. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)

Figure 2 Total NOS activity in rat SMA at different times. NOS activity was significantly enhanced in the SMA of the PVL-20G rats after 10 hours compared with the sham-operated rats. n = 3–6 per group per each time point. ∗P < 0.05 compared with corresponding sham-operated rats. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)

Figure 3 The perfusion pressure changes in response to methoxamine in isolated mesenteric arteries. (A) The comparison of contractile responses with methoxamine in the isolated mesenteric arterial beds of PVL-20G, PVL-18G, and sham rats. MTx30, methoxamine 30 μmol/L; MTx100, 100 μmol/L. n = 6 for sham, n = 8 for PVL-20G, and n = 6 for PVL-18G. ∗P < 0.05 compared with sham; ∗∗P < 0.05 compared with PVL-18G. (B) The comparison of contractile responses to methoxamine in mesenteric arterial beds isolated from the RAL and sham rats (n = 7 in each group; ∗P < 0.01). The SMA beds were isolated at 10 hours after RAL or sham operation. (C) Effects of NOS inhibition by l-NMMA on the contractile response to methoxamine in isolated mesenteric arterial beds. Preincubation with l-NMMA abolished the differences in the pressure response to methoxamine between the PVL-20G (n = 4) and sham (n = 5) groups. (D) Preincubation with l-NMMA abolished the differences in the pressure response to methoxamine between the RAL (n = 5) and sham (n = 4) groups. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)

Figure 4 Total NOS activity in homogenized SMA beds. (A) Total NOS activity in the SMA of the PVL (n = 5 for PVL-20G; n = 4 for PVL-18G) and the sham (n = 5) groups. ∗P < 0.05. Total NOS activity was significantly enhanced in the SMA of PVL-20G rats compared with PVL-18G and sham rats. (B) Total NOS activity in the SMA isolated 10 hours after RAL (n = 6) and sham (n = 6) operation. RAL exhibited significantly higher NOS activity compared with the sham rats. ∗P < 0.05. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)

Figure 5 eNOS and iNOS protein expression in SMA beds. (A) eNOS and iNOS protein expression in the SMA of the PVL (n = 4 for PVL-18G; n = 3 for PVL-20G) and the sham (n = 3) groups. Bovine aorta endothelial cell lysate was used as a positive control for eNOS. Lysate of peritoneal macrophages stimulated with lipopolysaccharide 100 ng/mL for 16 hours was used for the positive control for iNOS protein. (B) eNOS and iNOS protein expression in renal artery harvested 10 hours after RAL (n = 3) and sham (n = 3) operation. There was no significant difference in SMA eNOS expression in PVL-20G, PVL-18G, and RAL rats compared with the corresponding sham-operated rats. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)

Figure 6 Hemodynamic characteristics of PVL-20G, PVL-18G, and RAL and the sham-operated rats. (A) Hemodynamic study of the PVL and sham groups. PP, portal pressure; QSMA, SMA blood flow. ∗P < 0.05 compared with the sham group. Sham, n = 5; PVL-20G, n = 6; PVL-18G, n = 5. (B) Hemodynamic study of the RAL and sham groups. ∗P < 0.05. Sham, n = 6; RAL, n = 5. One-way analysis of variance followed by Scheffe test. Gastroenterology 2003 125, 1452-1461DOI: (10.1016/j.gastro.2003.07.014)