Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii,

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Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus S. Figueiredo, R.A. Bonnin, L. Poirel, J. Duranteau, P. Nordmann Clinical Microbiology and Infection Volume 18, Issue 9, Pages 907-913 (September 2012) DOI: 10.1111/j.1469-0691.2011.03708.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Amino acid alignment of β-lactamases OXA-211, OXA-213 and OXA-214 identified in this study from Acinetobacter johnsonii, Acinetobacter calcoaceticus, and Acinetobacter haemolyticus, respectively. Amino acid motifs that are well conserved (even if possibly variable) among class D β-lactamases (DBLs) are shaded in grey [19]. Numbering is according to DBL numbering [16]. Asterisks indicate identical amino acids between all sequences. Clinical Microbiology and Infection 2012 18, 907-913DOI: (10.1111/j.1469-0691.2011.03708.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Dendrogram obtained for 23 class D β-lactamases by neighbour-joining analysis. The alignment used for tree calculation was performed with ClustalX. Branch lengths are drawn to scale, and are proportional to the number of amino acid changes. The distance along the vertical axis has no significance. The class D β-lactamases that are considered to be naturally occurring are indicated, together with the names of the corresponding species. Clinical Microbiology and Infection 2012 18, 907-913DOI: (10.1111/j.1469-0691.2011.03708.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions