Correcting hyperkalemia in DCT-CA-SPAK mice with a low K diet corrects differences in ammonia excretion and inducing hyperkalemia in WT mice, with the.

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Correcting hyperkalemia in DCT-CA-SPAK mice with a low K diet corrects differences in ammonia excretion and inducing hyperkalemia in WT mice, with the ENaC inhibitor, benzamil, decreases urine ammonia excretion. Correcting hyperkalemia in DCT-CA-SPAK mice with a low K diet corrects differences in ammonia excretion and inducing hyperkalemia in WT mice, with the ENaC inhibitor, benzamil, decreases urine ammonia excretion. Subfigure (A) shows the effect of K+-restricted diet on plasma K+ and on urinary ammonia excretion. #P<0.01 versus baseline; *P<0.05 versus WT; **P<0.01 versus WT. n=6 in each genotype. Subfigure (B) shows that benzamil administration to wild-type mice progressively increased plasma K+ and decreased urinary ammonia excretion. n=5. DCT-CA-SPAK, mice with early DCT-specific over-expression of constitutively active SPAK; LK, low K diet; WT, wild-type mice. Autumn N. Harris et al. JASN 2018;29:1411-1425 ©2018 by American Society of Nephrology