The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: The Boston Circulatory Arrest Trial David.

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The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: The Boston Circulatory Arrest Trial David Wypij, PhD, Jane W Newburger, MD, MPH, Leonard A Rappaport, MD, Adre J duPlessis, MBChB, Richard A Jonas, MD, Gil Wernovsky, MD, Ming Lin, MS, David C Bellinger, PhD, MSc The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 5, Pages 1397-1403 (November 2003) DOI: 10.1016/S0022-5223(03)00940-1

Figure 1 Neurodevelopmental outcome as a function of duration of CA. The solid lines were derived from generalized additive models as a smooth function of duration of CA, with adjustment for diagnosis and family social class. The dashed lines present 95% confidence intervals, with the scatter plots denoting the raw data values. The P values assess whether there is any effect of duration of CA on outcomes, with adjustment for diagnosis and family social class. The panels represent Full-Scale IQ (A), Average Achievement (of Wechsler Reading and Mathematics Composite scores) (B), Grooved Pegboard (Dominant Hand) (C), and Mayo Test of Apraxia of Speech (D). The natural logarithm of the time to complete the Grooved Pegboard was used because this transformation yielded scores that were approximately normally distributed. The graph then exponentiates the results to return to the raw scale. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1397-1403DOI: (10.1016/S0022-5223(03)00940-1)

Figure 2 Estimated probabilities of apraxia diagnosis (A) and abnormal neurologic examination (B) as a function of the duration of total CA. The solid lines were derived from logistic regression curves, and the dashed lines present 95% confidence intervals. In addition, point estimates and exact 95% confidence intervals for outcome probabilities are plotted for the mean of each quartile of duration of CA. The P values were based on logistic regression for the effect of duration of CA on outcome, with adjustment for diagnosis. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1397-1403DOI: (10.1016/S0022-5223(03)00940-1)