Determinants of ischemic injury to skeletal muscle

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Presentation transcript:

Determinants of ischemic injury to skeletal muscle Paul F. Petrasek, MD, Shervanthi Homer-Vanniasinkam, MBBS, FRCS, Paul M. Walker, MD, PhD, FRCSC Journal of Vascular Surgery Volume 19, Issue 4, Pages 623-631 (April 1994) DOI: 10.1016/S0741-5214(94)70035-4 Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Muscle necrosis. Ischemic time, temperature, and residual flow each significantly influenced muscle necrosis; *p < 0.01 vs room-temperature ischemia group matching in ischemic time and residual flow, **p < 0.01 vs high residual flow ischemia group matching in ischemic time and temperature, § p < 0.01 vs 4-hour ischemia group matching in ischemic temperature and residual flow. Journal of Vascular Surgery 1994 19, 623-631DOI: (10.1016/S0741-5214(94)70035-4) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Distribution of muscle necrosis on basis of muscle fiber type. Predominantly fast-twitch fiber muscle (rectus femoris and anterior tibialis) had significantly greater necrosis than did slow-twitch muscles (semimembranosus proprius and soleus) after 5 hours of ischemia. No significant differences were observed after 4 hours of ischemia; *p ≤ 0.01, §p ≤ 0.05, fast-twitch vs slow-twitch fiber muscle. Journal of Vascular Surgery 1994 19, 623-631DOI: (10.1016/S0741-5214(94)70035-4) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Distribution of muscle necrosis on basis of muscle location. Necrosis was greater in proximal hindlimb muscles in all groups except those subjected to body-temperature ischemia; *p ≤ 0.01, proximal vs distal hindlimb. Journal of Vascular Surgery 1994 19, 623-631DOI: (10.1016/S0741-5214(94)70035-4) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Ischemic muscle weights. Ischemic-reperfused muscle weights are expressed as percentage of nonischemic weights measured in muscles of contralateral leg of each rabbit. Although muscles in all groups gained weight, differences between groups were not as great as those for muscle necrosis; *p ≤ 0.05 vs all 5-hour ischemia groups, § p ≤ 0.01 vs 5-hour high residual flow ischemia group and vs all 4-hour ischemia groups. Journal of Vascular Surgery 1994 19, 623-631DOI: (10.1016/S0741-5214(94)70035-4) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions