Volume 7, Issue 4, Pages (March 2001)

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Volume 7, Issue 4, Pages 245-250 (March 2001) Role of smooth muscle cell membrane potential in neointima formation in arteries of spontaneously hypertensive rats Jurandir J. Dalle Lucca, Antonio C.R. Borges, Renato Ponchirolli, Simone A.C.S. Melo, Silvia S.M. Ihara, Charles J. Lindsey, Therezinha B. Paiva Pathophysiology Volume 7, Issue 4, Pages 245-250 (March 2001) DOI: 10.1016/S0928-4680(00)00055-9

Fig. 1 Photomicrographs of representative cross-sections of uninjured and balloon injured aortas from WKY and SHR. A: uninjured WKY; B: uninjured SHR; C and E: injured WKY; D and F: injured SHR. Note the smaller neointimal formation in the SHR aorta. A, B, C and D, hematoxylin and eosin, ×25. E and F, immunohistochemistry labeled for smooth muscle α-actin, ×250. Adv, adventitia; M, media; NI, neointima. Pathophysiology 2001 7, 245-250DOI: (10.1016/S0928-4680(00)00055-9)

Fig. 2 Photomicrographs showing representative cross-sections of uninjured and balloon injured carotid arteries from WKY and SHR. A: uninjured WKY; B: uninjured SHR; C and E: injured WKY; D and F: injured SHR. Note the exaggerated fibroproliferative response of injured SHR carotid artery. A and B, hematoxylin and eosin, ×40. C, D, E and F, immunohistochemistry labeled for smooth muscle α-actin C and D×40, E and F×320. Adv: adventitia; M: media; NI: neointima. Pathophysiology 2001 7, 245-250DOI: (10.1016/S0928-4680(00)00055-9)

Fig. 3 Bar graph showing the inverse relationship between neointima formation and VSMC resting membrane potentials of aorta and carotid arteries from SHR and WKY rats. Neo/Media was determined 14 days after balloon injury. Resting membrane potentials were measured by intracellular recording of VSMC from non-injured arleries. *P<0.05 vs. WKY. †P<0.05 vs. aorta. Pathophysiology 2001 7, 245-250DOI: (10.1016/S0928-4680(00)00055-9)