Predictive performance of the modified Marsh and Schnider models for propofol in underweight patients undergoing general anaesthesia using target-controlled.

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Predictive performance of the modified Marsh and Schnider models for propofol in underweight patients undergoing general anaesthesia using target-controlled infusion Y.H. Lee, G.H. Choi, K.W. Jung, B.H. Choi, J.Y. Bang, E.K. Lee, B.M. Choi, G.J. Noh British Journal of Anaesthesia Volume 118, Issue 6, Pages 883-891 (June 2017) DOI: 10.1093/bja/aex102 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Measured (Cm) vs predicted (Cp) propofol concentrations for the (A) modified Marsh and (B) Schnider models. The filled and empty circles represent the data of patients allocated to the modified Marsh and Schnider groups, respectively. The red solid line shows the regression line. Cm = 1.02 × Cp − 0.67, R2=0.600 for the modified Marsh model; Cm = 1.06 × Cp + 0.24, R2=0.443 for the Schnider model. British Journal of Anaesthesia 2017 118, 883-891DOI: (10.1093/bja/aex102) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 The measured-to-predicted propofol concentration ratio (Cm/Cp) of the (A) modified Marsh, (B) Schnider and (C) Eleveld models. Data of all the patients (n=30) were used to calculate the Cm/Cp ratio of the three models. The red solid line shows the non-linear regression line. British Journal of Anaesthesia 2017 118, 883-891DOI: (10.1093/bja/aex102) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Simulated clearance of the modified Marsh (blue dotted line) and the Schnider (purple solid line) models based on the change in BMI. Age, sex and height were assumed as 35 yr, male and 165 cm, respectively. Clearance in the Schnider model was consistently higher than that in the modified Marsh model for underweight patients. The vertical black dotted line indicates a BMI of 18.5 kg m−2. British Journal of Anaesthesia 2017 118, 883-891DOI: (10.1093/bja/aex102) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 Simulated infusion rates over time to maintain a target effect-site concentration of 3 μg ml−1 for 60 min for the (A) modified Marsh, (B) Schnider and (C) Eleveld models in normal (BMI 20.5 kg m−2) and underweight (BMI 16.5 kg m−2) patients. Age, sex and height were assumed as 35 yr, male and 165 cm, respectively. British Journal of Anaesthesia 2017 118, 883-891DOI: (10.1093/bja/aex102) Copyright © 2017 The Author(s) Terms and Conditions