Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

What drives prescription patterns in pediatric asthma management?

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations Sigurd Broesby-Olsen, MD, Thomas Kielsgaard Kristensen,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

David A. Khan, MD Journal of Allergy and Clinical Immunology

Antti E. Seppo, PhD, Chloe A. Autran, MSc, Lars Bode, PhD, Kirsi M

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Joe K. Gerald, MD, PhD, Roni Grad, MD, William C. Bailey, MD, Lynn B

Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy Kamal D. Srivastava, PhD, Alyssa Siefert,

Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions Shelley F. Stone, PhD, Claire Cotterell,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Physician needs in health informatics: Just ask the docs

Morten J. Christensen, MD, Per Stahl Skov, MD, DMSci, Lars K

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Control lymphocyte subsets: Can one country's values serve for another's? Wilson L. Mandala, PhD, Jintanat Ananworanich, MD, PhD, Tanakorn Apornpong,

Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2 Phillip Lieberman, MD The Journal of Allergy.

Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation Zuotao Zhao, MD, PhD, Sascha Reimann, MD, Shan Wang, MD, Yuhan Wang, MD,

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Clinical characteristics of soybean allergy in Europe: A double-blind, placebo-controlled food challenge study Barbara K. Ballmer-Weber, MD, Thomas Holzhauser,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Airborne cat allergen reduction in classrooms that use special school clothing or ban pet ownership Anne-Sophie Karlsson, MSc, Berith Andersson, SRN,

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial Michael Weschta, MD, Dagmar Rimek,

Defining risk factors and presentations of allergic reactions to platelet transfusion William J. Savage, MD, PhD, Robert G. Hamilton, PhD, DAMBLI, Aaron.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

Risk of oral food challenges

Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract Anil Nanda, MD, Maeve O'Connor, MD,

Susan A. Rudders, MD, Sarah A. Arias, PhD, Carlos A

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Machine learning, natural language programming, and electronic health records: The next step in the artificial intelligence journey? Neil Mehta, MBBS,

Alvaro A. Cruz, MD, Robert M

Colin W. Summers, MSc, Richard S. Pumphrey, FRCPath, Charlotte N

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence Elizabeth A. Erwin, MD, Eva Rönmark, PhD, Kristin Wickens,

Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G

William J. Sheehan, MD, Helen A

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis Andrea L. Jones, MD, Douglas Curran-Everett, PhD,

Environmental factors and eosinophilic esophagitis

The prevalence and natural course of food protein–induced enterocolitis syndrome to cow’s milk: A large-scale, prospective population-based study Yitzhak.

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Double-blind, placebo-controlled study with a modified therapeutic vaccine of Salsola kali (Russian thistle) administered through use of a cluster schedule

The effects of gastric digestion on codfish allergenicity

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD, Esben Eller, MSc, PhD, Ulrik Sprogøe, MD, PhD, Torben Barington, MD, DMSci, Carsten Bindslev-Jensen, MD, PhD, DMSci Journal of Allergy and Clinical Immunology Volume 139, Issue 6, Pages 2015-2016.e4 (June 2017) DOI: 10.1016/j.jaci.2016.11.034 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The number of reacting recipients (gray bars) and the median Treact (●/erythema and o/wheal) in relation to the level of sIgE. The study includes 10 recipients sensitized with serum from donor 2 (Table E1) in 5 increasing concentrations. The oral peanut challenges were carried out as single dose (10 g of whole peanut). Journal of Allergy and Clinical Immunology 2017 139, 2015-2016.e4DOI: (10.1016/j.jaci.2016.11.034) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, The median Treact in relation to the challenge dose. B, The median Swheal in relation to the challenge dose. Both graphs (box plots) display the distribution of the data as follows: the median, the 25th and 75th percentiles (the boundary of the box), and the highest and lowest values (the whiskers above and below the box). All recipients were sensitized with donor serum 2, 3, and 4 (Table E1). The difference in the median Treact between all doses compared pairwise was statistically significant (P ≤ .003) except for the difference between 1 g and 3 g of peanut (P = .4). The difference in the median Swheal between the doses compared pairwise was statistically significant (P ≤ .001) except for the differences between 1 g and 3 g of peanut (P = .05) and 10 g and 100 g of peanut (P = .1). The asterisks indicate that a reaction was negative. Journal of Allergy and Clinical Immunology 2017 139, 2015-2016.e4DOI: (10.1016/j.jaci.2016.11.034) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 The median Treact in relation to the level of sIgE. The box plot displays the distribution of the data as follows: the median, the 25th and 75th percentiles (the boundary of the box), and the highest and lowest values (the whiskers above and below the box). The oral peanut challenges were carried out as single dose (10 g). The asterisks indicate that a reaction was negative. Journal of Allergy and Clinical Immunology 2017 139, 2015-2016.e4DOI: (10.1016/j.jaci.2016.11.034) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Open titrated oral peanut challenges. The study includes 14 recipients sensitized with serum from donor 2. The challenge doses of peanut were administered at 1-hour intervals. Journal of Allergy and Clinical Immunology 2017 139, 2015-2016.e4DOI: (10.1016/j.jaci.2016.11.034) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions