Atypical Primary Epithelioid Hemangioendothelioma of the Heart

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Atypical Primary Epithelioid Hemangioendothelioma of the Heart N Moulai, MD, O Chavanon, MD, PhD, L Guillou, MD, PhD, M Noirclerc, MD, D Blin, MD, E Brambilla, MD, S Lantuejoul, MD, PhD Journal of Thoracic Oncology Volume 1, Issue 2, Pages 188-189 (February 2006) DOI: 10.1016/S1556-0864(15)31539-2 Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1. Histological examination of the primary cardiac tumor revealed a proliferation of large epithelioid tumor cells presenting atypical features (arrow). Hematoxylin-eosin-saffron staining; original magnification ×400. Journal of Thoracic Oncology 2006 1, 188-189DOI: (10.1016/S1556-0864(15)31539-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2. Pulmonary metastasis corresponding to a classical nodular lesion, with a hypocellular fibrotic center and a more cellular periphery, composed of tumor cells that typically spread into the bronchioloalveolar lumen in a polypoid fashion. Hematoxylin-eosin-saffron staining; original magnification ×200. Journal of Thoracic Oncology 2006 1, 188-189DOI: (10.1016/S1556-0864(15)31539-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3. A, At higher magnification, epithelioid tumor cells harbor regular nuclei and large vacuolated cytoplasms containing rare red blood cells (arrow). Hematoxylin-eosin-saffron staining; original magnification ×400. B, CD 34 immunostaining enlightening primitive intracellular vascular channels (arrow). Immunoperoxidase staining; original magnification ×400. Journal of Thoracic Oncology 2006 1, 188-189DOI: (10.1016/S1556-0864(15)31539-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions