Ubiquitin Makes Its Mark on Immune Regulation

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni

Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

Diversity of Polyubiquitin Chains

Pathogen Recognition: TLRs Throw Us a Curve

Anergic B Cells Caught in the Act

cIAP Proteins: Keystones in NOD Receptor Signal Transduction

The Evolution of the Algorithms for Collective Behavior

The DNA Damage Response: Ten Years After

Volume 29, Issue 5, Pages (November 2008)

One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

Mind Bomb Proteins in the Antiviral Arsenal

Chronic Infections Capture Little Attention of the Masses

Maintaining Hematopoietic Stem Cells in the Vascular Niche

POPsicle for Fever! Cooling Down the Inflammasome

A View to a Kill: Structure of the RNA Exosome

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

PU.1 Takes Control of the Dendritic Cell Lineage

Copyright © 2012, Elsevier Inc. All rights Reserved.

Chronic Infections Capture Little Attention of the Masses

E Proteins Enforce Security Checkpoints in the Thymus

Michelle A. Linterman, Alice E. Denton Immunity

A Swiss Army Knife for CTLs

Ubiquitin-Proteasome: Pallbearer Carries the Deceased to the Grave

Proteasomes: Machines for All Reasons

Gut-Pancreatic Axis AMPlified in Islets of Langerhans

Keeping Transcriptional Activators under Control

Copyright © 2013 Elsevier Inc. All rights reserved.

Copyright © 2012, Elsevier Inc. All rights Reserved.

Pin-Pointing a New DAP Kinase Function: The Peptidyl-Proly Isomerase Pin1 Is Negatively Regulated by DAP Kinase-Mediated Phosphorylation Shani Bialik,

Copyright © 2012, Elsevier Inc. All rights Reserved.

Adding to the STING Immunity

Copyright © 2013 Elsevier Inc. All rights reserved.

A Prescription for Human Immunology

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains Till Maurer, Ingrid E. Wertz Molecular Cell

Michelle A. Linterman, Alice E. Denton Immunity

Living in Context with the Survival Factor BAFF

Modeling Functionality with Use Cases

Copyright © 2012, Elsevier Inc. All rights Reserved.

Rfu1: Stimulus for the Ubiquitin Economy

Eystein S. Husebye, Mark S. Anderson Immunity

MicroRNA-155 Function in B Cells

Eystein S. Husebye, Mark S. Anderson Immunity

Copyright © 2012, Elsevier Inc. All rights Reserved.

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Copyright © 2013 Elsevier Inc. All rights reserved.

The DNA Damage Response: Ten Years After

Homegrown Macrophages

Recycling Endosomes and TLR Signaling— The Rab11 GTPase Leads the Way

Copyright © 2012, Elsevier Inc. All rights Reserved.

t Testing the Immune System

S-Nitrosylation at the Interface of Autophagy and Disease

At 17, In-10's Passion Need Not Inflame

David Hubel and Torsten Wiesel

PTENtiating CFTR for Antimicrobial Immunity

Marking Emerging β- and γδ-Selected T Cells

Cellular Alchemy and the Golden Age of Reprogramming

IL-9 by INFERence Immunity

Of Human DC Migrants and Residents

Presentation transcript:

Ubiquitin Makes Its Mark on Immune Regulation Barbara A. Malynn, Averil Ma Immunity Volume 33, Issue 6, Pages 843-852 (December 2010) DOI: 10.1016/j.immuni.2010.12.007 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 A Diverse Array of Ubiquitin Chain Linkages Can Lead to Different Outcomes for the Substrate Protein and Result in Different Cellular Responses The colored circles denote monoubiquitin (black) or polyubiquitin chains denoted with various colors corresponding with different linkages, as defined by the arrows at left. Potential outcomes of substrate proteins conjugated with the given ubiquitin linkage are given in the box at right. Immunity 2010 33, 843-852DOI: (10.1016/j.immuni.2010.12.007) Copyright © 2010 Elsevier Inc. Terms and Conditions