Bettina Schreiner, Melanie Greter Cell Stem Cell

Slides:

Advertisements

Similar presentations

Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells Ying V. Zhang, Janice Cheong, Nichita Ciapurin,

Advertisements

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes Branden D. Tarlow, Carl Pelz, Willscott E. Naugler, Leslie.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Chemotherapy and Cancer Stem Cells

Cancer: Inappropriate Expression of Stem Cell Programs?

Scott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté

Finding Shangri-La: Limiting the Impact of Senescence on Aging

Volume 1, Issue 1, Pages (June 2007)

Human Induced Pluripotent Stem Cells: Now Open to Discovery

MicroRNA-124: Micromanager of Neurogenesis

Volume 12, Issue 2, Pages (February 2013)

Cell Cycle Rules Pluripotency

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

A Death Trap for Microglia

Upgrading from iMac to iMicro

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

Bettina Schreiner, Melanie Greter Cell Stem Cell

Gerry P. Crossan, Juan I. Garaycoechea, Ketan J. Patel Cell Stem Cell

Roger A. Barker, Malin Parmar, Lorenz Studer, Jun Takahashi

Anselme Perrier, Marc Peschanski Cell Stem Cell

MSCs, Macrophages, and Cancer: A Dangerous Ménage-à-Trois

Long Live Sox2: Sox2 Lasts a Lifetime

Regulating Cancer Stem Cells the miR Way

Wing Y. Chang, William L. Stanford Cell Stem Cell

Volume 11, Issue 3, Pages (September 2012)

Stem Cell Therapies in Clinical Trials: Progress and Challenges

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

Human Induced Pluripotent Stem Cells: Now Open to Discovery

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

TRRAP and the Maintenance of Stemness in Gliomas

Imported Stem Cells Strike against Stroke

Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders Liang Qiang, Ryousuke Fujita, Asa Abeliovich Neuron

Tim Willinger, Richard A. Flavell Cell Stem Cell

Putting Two Heads Together to Build a Better Brain

Commanding CNS Invasion: GM-CSF

Amyloid Cascade into Clarity

Volume 18, Issue 2, Pages (February 2016)

Pluripotent Stem Cells and Disease Modeling

Roger A. Barker, Malin Parmar, Lorenz Studer, Jun Takahashi

Mohammad Abdul-Ghani, Lynn A. Megeney Cell Stem Cell

Meddling with METTLs in Normal and Leukemia Stem Cells

Volume 21, Issue 1, Pages (July 2017)

Bmi1 and Cell of Origin Determinants of Brain Tumor Phenotype

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Stem Cells and Osteoporosis Therapy

Microglia: Multitasking Specialists of the Brain

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

Selfish Stem Cells Compete with Each Other

Long Live Sox2: Sox2 Lasts a Lifetime

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Chapter 29 - Stem Cells and Generation of New Cells in the

Mesp1 at the Heart of Mesoderm Lineage Specification

Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs

Cellular Alchemy and the Golden Age of Reprogramming

Modeling Brain Disease in a Dish: Really?

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

Presentation transcript:

EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration Bettina Schreiner, Melanie Greter Cell Stem Cell Volume 21, Issue 5, Pages 566-568 (November 2017) DOI: 10.1016/j.stem.2017.10.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Targeting Braf(V600E) in Microglia Causes Neurodegenerative Disease Tamoxifen administration at E8.5 leads to the mosaic expression of Braf(V600E) in erythro-myeloid precursors (EMPs). EMPs in the yolk sac (YS) differentiate into primitive macrophages (MF) and colonize the developing brain where they give rise to microglia. In adult mice, microglia display an activated phenotype leading to neurodegenerative disease including deposition of amyloid precursor protein (APP), neuronal death, and demyelination. Braf inhibition delays the onset of the neurological phenotype. Cell Stem Cell 2017 21, 566-568DOI: (10.1016/j.stem.2017.10.006) Copyright © 2017 Elsevier Inc. Terms and Conditions