Bioinformatics analysis of the small TbTim amino acid sequences.

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Bioinformatics analysis of the small TbTim amino acid sequences. Bioinformatics analysis of the small TbTim amino acid sequences. (A to D) Clustal Omega multiple-sequence alignment of the primary amino acid sequences of (A) TbTim9, HsTim9, ScTim9, and AtTim9; (B) TbTim10, HsTim10, ScTim10, and AtTim10; (C) TbTim8/13, HsTim8a, HsTim8, ScTim8, and AtTim8; and (D) TbTim8/13, HsTim13, HsTim13, ScTim13, and AtTim13 (ScTim, Saccharomyces cerevisiae Tim; HsTim, Homo sapiens Tim; AtTim, Arabidopsis thaliana Tim). Identical amino acid residues are highlighted in black; similar amino acid residues are highlighted in gray. (E to G) Protein structure homology modeling using the SWISS-MODEL ExPASy Web server based on available crystal structures. The PDB numbers for the crystal structures used as templates are as follows: ScTim10, 3dxr.1.B; HsTim10a, 2bsk.1.B; HsTim9, 2bsk.1.A. The top three predicted tertiary structure models of (E) TbTim9, (F) TbTim10, and (G) TbTim8/13 are shown from most probable best fit to least probable best fit from left to right. The small Tim homologue that was used as the template is shown below the corresponding best-fit model. All protein models are shown with the N terminus on the left and the C terminus on the right. Blue indicates regions of conserved tertiary structure, and orange indicates regions of divergent tertiary structure. Joseph T. Smith Jr. et al. mSphere 2018; doi:10.1128/mSphere.00204-18