Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines Chakkumkal Anish, Benjamin Schumann, Claney Lebev Pereira, Peter H. Seeberger  Chemistry & Biology  Volume 21, Issue 1, Pages 38-50 (January 2014) DOI: 10.1016/j.chembiol.2014.01.002 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 The Immunogenic Determinants of a Synthetic Carbohydrate Antigen Size/span of the epitope (1), terminal glycan residues (2), presence of branching points (3), side chain functional groups (4), and number of repeating units (5). L, preinstalled linker for conjugation. Chemistry & Biology 2014 21, 38-50DOI: (10.1016/j.chembiol.2014.01.002) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Major Steps Involved in Rational Design of Synthetic Carbohydrate Vaccines ∗Reprinted with permission from Oberli et al. (2010). Copyright (2010) American Chemical Society. Chemistry & Biology 2014 21, 38-50DOI: (10.1016/j.chembiol.2014.01.002) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 The Structure of Man9GlcNAc2 on HIV Protein gp120 Interacting with the Broadly Neutralizing mAb 2G12 Adapted from Lee et al. (2004). Chemistry & Biology 2014 21, 38-50DOI: (10.1016/j.chembiol.2014.01.002) Copyright © 2014 Elsevier Ltd Terms and Conditions