Altered gait mechanics and elevated serum pro-inflammatory cytokines in asymptomatic patients with MRI evidence of knee cartilage loss S.N. Edd, J. Favre,

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Altered gait mechanics and elevated serum pro-inflammatory cytokines in asymptomatic patients with MRI evidence of knee cartilage loss S.N. Edd, J. Favre, K. Blazek, P. Omoumi, J.L. Asay, T.P. Andriacchi Osteoarthritis and Cartilage Volume 25, Issue 6, Pages 899-906 (June 2017) DOI: 10.1016/j.joca.2016.12.029 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Examples of MRI evidence of (a) partial-thickness cartilage loss (between arrows) and (b) full-thickness cartilage loss (between arrows) and bone marrow edema (arrowhead). Osteoarthritis and Cartilage 2017 25, 899-906DOI: (10.1016/j.joca.2016.12.029) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Stance knee flexion angle (a) and flexion moment (b) for Pre-OA (n = 52; red solid) and Control (n = 26; blue dashed) groups. Error bars represent one standard deviation on both sides of the mean. *Indicates Benjamini–Hochberg significance with α = 0.05. Osteoarthritis and Cartilage 2017 25, 899-906DOI: (10.1016/j.joca.2016.12.029) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Median and quartile ranges of TNFα serum concentration in Pre-OA (n = 47, mean of 2 measures per subject) and Control (n = 24, mean of 2 measures per subject) subjects. *Indicates bootstrap t-test significant difference between groups, P < 0.05. Osteoarthritis and Cartilage 2017 25, 899-906DOI: (10.1016/j.joca.2016.12.029) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions