Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability.

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Presentation transcript:

Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability transition pore R. Huhn, A. Heinen, N.C. Weber, M.W. Hollmann, W. Schlack, B. Preckel British Journal of Anaesthesia Volume 100, Issue 4, Pages 465-471 (April 2008) DOI: 10.1093/bja/aen022 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a) Experimental protocol. Sevo, sevoflurane; post, postconditioning; HG, hyperglycaemia; CsA, cyclosporine A. (b) Infarct size measurement. Histogram shows the infarct size (per cent of area at risk, AAR) of controls (Con), sevoflurane postconditioning (Sevo), hyperglycaemia (HG) alone, hyperglycaemia and sevoflurane postconditioning (HG+Sevo), cyclosporine A (CsA) alone, cyclosporine A and sevoflurane postconditioning (CsA+Sevo), hyperglycaemia and cyclosporine A (HG+CsA), hyperglycaemia and cyclosporine A and sevoflurane postconditioning (HG+CsA+Sevo), hyperglycaemia and sevoflurane postconditioning with 2 MAC (HG+Sevo2), hyperglycaemia and cyclosporine A with 10 mg kg−1 (HG+CsA10). Data shown are mean (sd). *P<0.05 vs control group; #P<0.05 vs HG+Sevo; §P<0.05 vs HG+CsA (n = 7–11 per group). British Journal of Anaesthesia 2008 100, 465-471DOI: (10.1093/bja/aen022) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions