Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats A. Brücken, A. Cizen, C. Fera, A. Meinhardt,

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Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats A. Brücken, A. Cizen, C. Fera, A. Meinhardt, J. Weis, K. Nolte, R. Rossaint, T. Pufe, G. Marx, M. Fries British Journal of Anaesthesia Volume 110, Pages i106-i112 (June 2013) DOI: 10.1093/bja/aes509 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 NDS on all days after CPR. Severe neurological dysfunction could be measured with the NDS in all control animals (n=7). Argon-treated animals (n=7) showed a significantly better NDS through all postoperative days. *P<0.05 vs control; mean (sd). British Journal of Anaesthesia 2013 110, i106-i112DOI: (10.1093/bja/aes509) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 The open field test on day 4 after CPR evaluates the animal's normal exploratory behaviour and spontaneous locomotor activity. Argon-treated animals (n=7) were significantly more mobile, moved significantly more time along the walls than control animals (n=7), which stayed more in the corners. *P<0.05 vs control; mean (sd). British Journal of Anaesthesia 2013 110, i106-i112DOI: (10.1093/bja/aes509) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 (a) Histopathological evaluation of all regions of interest in control (n=7) and argon (n=7)-treated animals. *P<0.05 vs control; mean (sd). (b) Representative photomicrographs of the hippocampal sector CA 3/4 showing numerous ischaemically (damaged neurones (black arrows) in a control animal and almost no necrosis in an argon-treated animal. British Journal of Anaesthesia 2013 110, i106-i112DOI: (10.1093/bja/aes509) Copyright © 2013 The Author(s) Terms and Conditions