Incomplete Repressors in Phages

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Presentation transcript:

Incomplete Repressors in Phages Mandi Feinberg BNFO 301 Spring 2013

Phages Bacteria

Phages

Mycobacteria Phages

Limitations When I find motifs that may be incomplete– won’t know what phage it belongs to since I used randomization and MEME only gives sequence numbers so its impossible match it back Have to go through in sections and label them and find motifs in order Limited to about 20 before times out No matter how fix it, it will be a long, complicated process

Works Cited http://www.sciencedirect.com/science/article/pii/S1097276512009434 Broussard, Gregory W., Lauren M. Oldfield, Valerie M. Villanueva, Bryce L. Lunt, Emilee E. Shine, and Graham F. Hatfull. "Integration-Dependent Bacteriophage Immunity Provides Insights into the Evolution of Genetic Switches." Molecular Cell 49 (2013): 237-48. http://biobike.phantome.org/ajax/vpl.html?PKG=FEINBERGMA39619 Intro to BNFO 301 Exam 2 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC94198/ The Genetic Switch Regulating Activity of Early Promoters of the Temperate Lactococcal Bacteriophage TP901-1 Peter Lynge Madsen, Annette H. Johansen, Karin Hammer, Lone Brøndsted J Bacteriol. 1999 December; 181(24): 7430–7438.