Growth Control: Myc and Yorkie Get Connected Hugo Stocker  Current Biology  Volume 21, Issue 1, Pages R37-R39 (January 2011) DOI: 10.1016/j.cub.2010.11.057 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Negative feedback loop involving the growth promoters Yki and dMyc. dMyc is transcriptionally induced by Yki/Sd. The proto-oncoprotein dMyc keeps Yki levels in check, thereby limiting its own expression. The Hippo pathway controls Yki activity by countering its nuclear translocation. Thus, Hippo signaling and the negative feedback mediated by dMyc cooperate to prevent unrestricted growth caused by nuclear Yki. Current Biology 2011 21, R37-R39DOI: (10.1016/j.cub.2010.11.057) Copyright © 2011 Elsevier Ltd Terms and Conditions