R. H. J. Das, M. Sc. , H. Jahr, Ph. D. , J. A. N. Verhaar, M. D. , Ph

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Presentation transcript:

In vitro expansion affects the response of chondrocytes to mechanical stimulation R.H.J. Das, M.Sc., H. Jahr, Ph.D., J.A.N. Verhaar, M.D., Ph.D., J.C. van der Linden, Ph.D., G.J.V.M. van Osch, Ph.D., H. Weinans, Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 3, Pages 385-391 (March 2008) DOI: 10.1016/j.joca.2007.07.014 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Layout of experimental set-up. Osteoarthritis and Cartilage 2008 16, 385-391DOI: (10.1016/j.joca.2007.07.014) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Relative gene expression levels of unstretched primary chondrocytes vs expanded (P3) chondrocytes. * Indicates significant difference (P<0.05). Osteoarthritis and Cartilage 2008 16, 385-391DOI: (10.1016/j.joca.2007.07.014) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Gene expression of primary chondrocytes under strain (0.5% and 3.0%) relative to unstrained controls. * Indicates statistically significant difference with control (P<0.05). Osteoarthritis and Cartilage 2008 16, 385-391DOI: (10.1016/j.joca.2007.07.014) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Gene expression of expanded, dedifferentiated chondrocytes under strain (0.5% and 3.0%) relative to unstrained controls. * Indicates statistically significant difference with control (P<0.05). Osteoarthritis and Cartilage 2008 16, 385-391DOI: (10.1016/j.joca.2007.07.014) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Gene expression of expanded, dedifferentiated chondrocytes in a chondrogenic environment under strain (0.5% and 3.0%) relative to unstrained controls. * Indicates statistically significant difference with control (P<0.05). Osteoarthritis and Cartilage 2008 16, 385-391DOI: (10.1016/j.joca.2007.07.014) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions