Temporal Trends in Initiation of Therapy With Tumor Necrosis Factor Antagonists for Patients With Inflammatory Bowel Disease: A Population-based Analysis

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Presentation transcript:

Temporal Trends in Initiation of Therapy With Tumor Necrosis Factor Antagonists for Patients With Inflammatory Bowel Disease: A Population-based Analysis Laura E. Targownik, Aruni Tennakoon, Stella Leung, Lisa M. Lix, Harminder Singh, Charles N. Bernstein Clinical Gastroenterology and Hepatology Volume 15, Issue 7, Pages 1061-1070.e1 (July 2017) DOI: 10.1016/j.cgh.2017.01.035 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Point prevalence of anti-TNF use by calendar date. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Cumulative prevalence of anti-TNF use by calendar date. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Time between initial diagnosis of IBD and initial receipt of anti-TNF. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Time until initial receipt of anti-TNF from first IM dispensation or first instance of corticosteroid dependence, by era of diagnosis. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 5 Comparison of individual cumulative corticosteroid dosing between eras, matched on time from diagnosis until anti-TNF use. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Time from disease onset to time to first anti-TNF, by severity of disease in first year after diagnosis. Clinical Gastroenterology and Hepatology 2017 15, 1061-1070.e1DOI: (10.1016/j.cgh.2017.01.035) Copyright © 2017 AGA Institute Terms and Conditions