acquired immunity humoral response antibodies (tag invaders) diversity (CDR) five major types… secreted, circulating, tissue (IgA…) produced by B cells (clones) cell mediated response B cells (plasma, memory) TH cells TC cells (cytotoxic) macrophages, PMNLs communication via cytokines
Fab VH VL CH3 CL CH2 CH1 Fc
“framework”
CDR
Fab VH VL CH3 CL CH2 CH1 Fc
acquired immunity humoral response antibodies (tag invaders) diversity (CDR) five major types… secreted, circulating, tissue produced by B cells cell mediated response B cells (plasma, memory) TH cells TC cells macrophages communication via cytokines
acquired immunity invader… antigen (epitope, determinant) five main kinds: viruses, bacteria, fungi, “protozoa”, metazoan parasites antigen (epitope, determinant)
acquired immunity antibody diversity antigen independent proliferation B cell B cell antibody diversity antigen independent proliferation B cell
acquired immunity B cell
acquired immunity B cell MAC
acquired immunity B cell MAC
acquired immunity B cell MAC
acquired immunity B cell MAC MHC APC
acquired immunity B cell MAC TH
acquired immunity B cell MAC TH
TH acquired immunity B cell TH MAC TH TH TH
acquired immunity B cell MAC TH
acquired immunity plasma B cells anitgen dependent proliferation memory B cell
acquired immunity plasma B cells memory B cell B cell B cell B cell
acquired immunity plasma B cells ?? memory B cell B cell B cell B cell
acquired immunity MAC MAC MAC MAC
acquired immunity MAC MAC MAC MAC
acquired immunity B cell memory B cell
acquired immunity plasma B cells memory B cell B cell B cell B cell
acquired immunity plasma B cells memory B cell B cell B cell B cell
acquired immunity MAC MAC MAC B cell memory B cell MAC
acquired immunity PMNLs
acquired immunity PMNLs ADCC… ROSs RNSs Perforins
acquired immunity PMNLs ADCC… ROSs RNSs Perforins
acquired immunity MAC
acquired immunity
acquired immunity
acquired immunity APC
acquired immunity TH
acquired immunity TC TH
acquired immunity TC perforins… apoptosis
acquired immunity TC
basics of epidemiology the study of diseases in populations endemic disease… epidemic disease… pandemic disease…
basics of epidemiology
basics of epidemiology the chain of infection…
basics of epidemiology The pathogen isolate identify associate introduce the chain of infection…
basics of epidemiology The source humans animals the chain of infection…
basics of epidemiology Transmission contact airborne the environment vectors the chain of infection…
basics of epidemiology Susceptibility virulence immunity the chain of infection…
basics of epidemiology Exit from host sanitation hygiene exposure to vector the chain of infection…