+ + Co-crystal occurrence/ Supramolecular yield 3/48 N,N’-heterocycle Supramolecular Synthesis of Molecular Co-crystals: A Versatile Approach to Modulating Physical Properties of Functional Molecular Solids Christer B. Aakeröy, Kansas State University, Manhattan, KS, 66505 Co-crystal occurrence/ Supramolecular yield + 3/48 7% pKa values: 10.80-11.40 N,N’-heterocycle + 16/16 100% pKa values: 9 N,N’-heterocycle We have shown that a modular and hierarchical view of intermolecular forces can offer reliable guidelines for non-covalent supramolecular synthesis.