Rare desmin variant causing penetrant life-threatening arrhythmic cardiomyopathy Ad W.G.J. Oomen, MD, Katherine Jones, BSc, BTeach, Laura Yeates, BSc.

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Presentation transcript:

Rare desmin variant causing penetrant life-threatening arrhythmic cardiomyopathy Ad W.G.J. Oomen, MD, Katherine Jones, BSc, BTeach, Laura Yeates, BSc GDipGC, Christopher Semsarian, MBBS, PhD, MPH, FHRS, Jodie Ingles, MPH, PhD, Raymond W. Sy, MBBS, PhD, FHRS HeartRhythm Case Reports Volume 4, Issue 7, Pages 318-323 (July 2018) DOI: 10.1016/j.hrcr.2018.04.007 Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 1 A: Twelve-lead electrocardiogram showing complete atrioventricular block. B: Monitor strip from an external defibrillator showing ventricular fibrillation. C: Pacemaker interrogation showing onset of ventricular fibrillation. AS = atrial sensed event; PVC = premature ventricular contraction; VP = ventricular paced event; VS = ventricular sensed event. HeartRhythm Case Reports 2018 4, 318-323DOI: (10.1016/j.hrcr.2018.04.007) Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 2 Twelve-lead electrocardiogram showing complete atrioventricular block. HeartRhythm Case Reports 2018 4, 318-323DOI: (10.1016/j.hrcr.2018.04.007) Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 3 A: Schematic representation of desmin in relation to other proteins involved in the cytoarchitecture of the myocyte. B: Protein structure of desmin showing precoil domain (PCD) and rod domains. The Arg454Trp causative variant is highlighted in the tail region. HeartRhythm Case Reports 2018 4, 318-323DOI: (10.1016/j.hrcr.2018.04.007) Copyright © 2018 Heart Rhythm Society Terms and Conditions